PEPERONI

Project PlacEntal PERfusion
and OxygeNation Imaging

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Project PlacEntal PERfusion and OxygeNation Imaging

In PEPERONI (PlacEntal PERfusion and OxygeNation Imaging), we use cutting-edge imaging to monitor how well the placenta works. The placenta, a unique and vital organ, is shared by the mother and her offspring during pregnancy. In this study, we are using advanced MRI imaging methods to assess how the placenta performs essential functions, such as perfusion (blood flow) and oxygenation. Ultimately, PEPERONI will provide data that could enable us to develop optimal treatments for pregnancies complicated by placental failure and to ensure the best possible outcomes for future babies.

We use MRI, an advanced imaging technique, to safely examine the unborn baby and the placenta that safeguards it during pregnancy.

Purpose

In PEPERONI (PlacEntal PERfusion and OxygeNation Imaging) we use cutting-edge imaging to monitor how well the placenta works. The placenta, a unique and vital organ, is shared by the mother and her offspring during pregnancy and supports the baby’s normal growth and development. The placenta delivers oxygen and nutrients to the growing fetus and ferries away waste products that otherwise would acumulate in the baby’s blood. The placenta’s major functions are exchange of gases (like oxygen), metabolic transfer, producing hormones and safeguarding the growing baby from dangers, such as infectious agents the mother is exposed to during pregnancy. In this study, we are using advanced MRI imaging methods to assess how the placenta performs its essential functions. Ultimately, PEPERONI will provide data that could enable us to develop optimal treatments for pregnancies complicated by placental failure and to ensure the best possible outcomes for future babies.

FAQ

What should I expect?

Before your baby is born, you will meet us in person to take special pictures (or scans) of your baby using safe, non-invasive magnetic resonance imaging (MRI)
These MRI scans will occur up to three times:

13 to 19 weeks gestation
23 to 29 weeks gestation
33 to 38 weeks gestation

Who can participate

Women older than 18 with a singleton pregnancy
Women in the second and third trimester of pregnancy (13 to 38 weeks gestation)
Women who are either

healthy
diagnosed with fetal growth restriction
diagnosed with preeclampsia

Who may not participate

Women expected to give birth to more than one child
Pregnant women unable to enter an MRI
Fetuses with dysmorphic features or dysgenetic lesions, or documented genetic or chromosomal abnormalities

Will I be paid?

You will receive free parking during your PEPERONI study-related visits to Children's National
You will receive $100 compensation for each study-related visit to Children’s National
You will be given free MRI pictures of your developing baby