Catherine Limperopoulos PH.D.

Catherine Limperopoulos, Ph.D., is the founding Director of the Developing Brain Institute and Director of the Advanced Pediatric Brain Imaging Research Program at Children’s National Hospital and Professor of Neurology, Radiology and Pediatrics at the George Washington University School of Medicine & Health Sciences.

The Developing Brain Institute has assembled leading scientists and health care providers from across myriad disciplines and health care models (tertiary care to primary care) at that are at the forefront of clinical research and translational efforts focused on accelerating screening, diagnosing, treating and preventing prenatal onset brain disorders to improve child health and well-being for life. Dr. Limperopoulos’ research seeks to understand the impact of an adverse intra- and extra-uterine environment on the developing fetal brain and its long-term neurodevelopmental repercussions. She is an occupational therapist and pediatric neuroscientist who has demonstrated repeated successes in completing novel patient-centered clinical and translational research in healthy and high-risk pregnant women and neurodiagnostic and neurodevelopmental surveillance in high-risk fetuses and preterm infants. She has or has had funding from the National Institutes of Health, Canadian Institutes of Health Research, the Department of Defense, the Centers for Disease Control and Prevention and private foundations, like the A. James & Alice B. Clark Foundation. She has authored more than 140 peer-reviewed publications. She also leads the Integrating Special Populations Module of the CNMC-GW NIH Clinical and Translational Science Award, which focuses on improving recruitment and retention of disadvantaged women into preventative maternal-fetal clinical trials aimed at optimizing long-term, maternal-infant health and well-being. She co-leads the DC Mother-Baby Wellness Network, funded by a June 2020 investment from the A. James & Alice B. Clark Foundation. The Network is a city-wide effort to create new interventions to reduce mental health issues commonly experienced by pregnant, low-income women.

Dr. Limperopoulos is founder and director of the DC Perinatal Mental Health Consortium, which brings together multiple stakeholders from our regional (Washington, D.C.) health care partners in obstetrics, psychiatry and pediatrics and an established community advisory board with representation of stakeholders from low-income, African American communities including DC-Primary Care Association, Mary’s Center, Community of Hope, Unity Health, DC-Primary care center, Mamatoto Village and African American patients, representatives with expertise in advocacy and policy. The overarching mission of this DC collaborative is to determine the optimal delivery of screening and low-cost interventions aimed at reducing the striking health disparities experienced by low-income women in the District of Columbia.


Address: 111 Michigan Ave NW, Washington, DC 20010
Department: MRI Lab

Recent Publications & Presentations

De Asis-Cruz J, Krishnamurthy D, Zhao L, Kapse K, Vezina G, Andescavage N, Quistorff J, Lopez C, Limperopoulos C.
Association of prenatal maternal anxiety with fetal regional brain connectivity JAMA Network Open. Published 2020, Dec. 7;3(12):e2022349. doi:10.1001/jamanetworkopen.2020.22349 https://pubmed.ncbi.nlm.nih.gov/33284334/
De Asis-Cruz J, Kapse K, Basu SK, Said M, Scheinost D, Murnick J, Chang T, du Plessis A, Limperopoulos C.
Functional brain connectivity in ex utero premature infants compared to in utero fetuses
[published online ahead of print, 2020 Jun 11]. Neuroimage. 2020;219:117043. doi:10.1016/j.neuroimage.2020.117043 https://pubmed.ncbi.nlm.nih.gov/32534962/
Ottolini KM, Andescavage N, Kapse K, Jacobs M, Murnick J, VanderVeer R, Basu S, Said M, Limperopoulos C.
Early lipid intake improves cerebellar growth in very low-birth-weight preterm infants
[published online ahead of print, 2020 May 8]. JPEN J Parenter Enteral Nutr. 2020;10.1002/jpen.1868. doi:10.1002/jpen.1868 https://pubmed.ncbi.nlm.nih.gov/32384168/
Andescavage N, You W, Jacobs M, Kapse K, Quistorff J, Bulas D, Ahmadzia H, Gimovsky A, Baschat A, Limperopoulos C.
Exploring in vivo placental microstructure in healthy and growth-restricted pregnancies through diffusion-weighted magnetic resonance imaging. Placenta.2020 Apr;93:113-118. doi: 10.1016/j.placenta.2020.03.004. Epub 2020 Mar 6. https://pubmed.ncbi.nlm.nih.gov/32250735/
Wu Y, Stoodley C, Brossard-Racine M, Kapse K, Vezina G, Murnick J, du Plessis, AJ, Limperopoulos C.
Altered local cerebellar and brainstem development in preterm infants. Neuroimage. 2020 Jun;213:116702. doi: 10.1016/j.neuroimage.2020.116702. Epub 2020 Mar 5. https://pubmed.ncbi.nlm.nih.gov/32147366/
Fumagalli M, Parodi A, Ramenghi L, Limperopoulos C, Steggerda S.
Ultrasound of acquired posterior fossa abnormalities in the newborn. Pediatric Research. 2020 Mar;87 (Supple 1):25-36. doi: 10.1038/s41390-020-0778-9. PMID: 32218537. https://pubmed.ncbi.nlm.nih.gov/32218537/
Wu Y, Lu YC, Jacobs M, Pradhan S, Kapse K, Zhao L, Andescavage N, Vezina G, du Plessis A, Limperopoulos C.
Association of prenatal maternal psychological distress with fetal brain growth, metabolism, and cortical maturation. JAMA Network Open. 2020 Jan 3;3(1):e1919940. doi: 10.1001/jamanetworkopen.2019.19940. PMC6991285 https://pubmed.ncbi.nlm.nih.gov/31995213/
Wu Y, Kapse K, Jacobs M, Andescavage N, Donofrio MT, Krishnan A, Vezina G, Wessel D, du Plessis A, Limperopoulos C.
Association of maternal psychological distress with in utero brain development in fetuses with congenital heart disease. JAMA Pediatrics. 2020 Jan 13; doi:10.1001/jamapediatrics.2019.5316 PMCID: PMC6990726 https://pubmed.ncbi.nlm.nih.gov/31930365/
Ottolini KM, Andescavage N, Kapse K, Jacobs M, Limperopoulos C.
Improved brain growth and microstructural development in breast milk-fed very low birth weight premature infants. Acta Paediatrica. 2020 Jan 10. doi: 10.1111/apa.15168. [Epub ahead of print] https://pubmed.ncbi.nlm.nih.gov/31922288/
You W, Andescavage N, Kapse K, Donofrio MT, Jacobs M, Limperopoulos C.
Hemodynamic responses of the placenta and brain to maternal hyperoxia in fetuses with congenital heart disease by using Blood Oxygen–Level Dependent MRI. Radiology 2020 Jan; 294(1):141-148. doi: 10.1148/radiol.2019190751. Epub 2019 Nov 5. https://pubmed.ncbi.nlm.nih.gov/31687920/
Bouyssi-Kobar M, De Asis-Cruz J, Murnick J, Chang T, Limperopoulos C.
Altered functional brain network integration, segregation and modularity in very preterm infants at term equivalent age. Journal of Pediatrics 2019;213:13-21.e1. doi:10.1016/j.jpeds.2019.06.030 https://pubmed.ncbi.nlm.nih.gov/31358292/
Ottolini KM, Andescavage N, Keller S, Limperopoulos C.
Nutrition and the developing brain: the road to optimizing early neurodevelopment: a systematic review. Pediatric Research. 2019 Jul 26. doi: 10.1038/s41390-019-0508-3. [Epub ahead of print] PMID: 31349359 https://pubmed.ncbi.nlm.nih.gov/31349359/
Andescavage N, Dahdouh S, Jacobs M, Yewale S, Bulas D, Iqbal S, Baschat A, Limperopoulos C.
In vivo textural and morphometric analysis of placental development in healthy & growth-restricted pregnancies using magnetic resonance imaging. Pediatrics Research. 2019 Jun 25; 85(7):974-81. doi: 10.1038/s41390-019-0311-1. Epub 2019 Jan 25. PMCID: PMC6531319 https://pubmed.ncbi.nlm.nih.gov/30700836/
Schlatterer SD, Murnick J, Jacobs M, White L, Donofrio MT, Limperopoulos C.
Placental pathology and neuroimaging correlates in neonates with congenital heart disease. Scientific Reports. 2019 Mar 11;9(1):4137. doi: 10.1038/s41598-019-40894-y. PMCID: PMC6411739 https://pubmed.ncbi.nlm.nih.gov/30858514/
Basu S, Pradhan S, Kapse K, McCarter R, Murnick J, Chang T, Limperopoulos C.
Third trimester cerebellar metabolite concentrations are decreased in very premature infants with structural injury. Scientific Reports. 2019 Feb 4;9(1):1212. doi: 10.1038/s41598-018-37203-4. https://pubmed.ncbi.nlm.nih.gov/30718546/
You W, Andescavage N, Kapse K, Donofrio M, Jacobs M, Limperopoulos C.
Altered hemodynamic responses of the placenta and fetal brain to maternal hyperoxia in the fetus with congenital heart disease. Circulation. 2019 Jan 10. (Accepted)
Brossard-Racine M, McCarter R, Murnick J, Tinkelman L, Vezina G, Limperopoulos C.
Early extra-uterine exposure alters regional cerebellar growth in infants born preterm. NeuroImage: Clinical. 2019;21:101646. doi: 10.1016/j.nicl.2018.101646. Epub 2018 Dec 19 https://pubmed.ncbi.nlm.nih.gov/30630759/
Krishnan A, Tague L, Rudra H, Pradhan S, Vezina G, Limperopoulos C.
Clinical course of a fetus with hypoplastic left heart syndrome and premature ductal constriction. Cardiol Young. 2018 Dec 27:1-3. doi: 10.1017/S1047951118001701. [Epub ahead of print] https://pubmed.ncbi.nlm.nih.gov/30587271/
Hernandez-Castillo C, Limperopoulos C, Diedrichsen J.
A representative template of the neonatal cerebellum. NeuroImage. 2018 Sep 19;184:450-454. doi: 10.1016/j.neuroimage.2018.09.048. PMID 30243975 https://pubmed.ncbi.nlm.nih.gov/30243975/
You W, Xu F, Limperopoulos C.
Linear convolution model of fetal circulation for hemodynamic responses to maternal hyperoxia using in utero functional MRI. Biomedical Imaging (ISBI 2018), 2018 IEEE 15th International Symposium on Biomedical Imaging. 2018 Apr;2018:1284-7. doi: 10.1109/ISBI.2018.8363806 https://pubmed.ncbi.nlm.nih.gov/29899816/
Bouyssi-Kobar M, Brossard-Racine M, Jacobs M, Murnick J, Chang T, Limperopoulos C.
Regional microstructural organization of the cerebral cortex is affected by preterm birth. NeuroImage:Clinical. 2018;18:871-880. doi: 10.1016/j.nicl.2018.03.020 https://pubmed.ncbi.nlm.nih.gov/29876271/
Mahdi E, Murnick J, Limperopoulos C.
Cerebral perfusion is perturbed by preterm birth and brain injury. American Journal of Neuroradiology. 2018; 39(7):1330-1335. PMID: 2974820 https://pubmed.ncbi.nlm.nih.gov/29748205/
Zun Z, Limperopoulos C.
Placental perfusion imaging using velocity selective arterial spin labeling. Magnetic Resonance in Medicine. 2018 Sep;80(3):1036-1047. PMID:29436733 https://pubmed.ncbi.nlm.nih.gov/29436733/