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Catherine Limperopoulos PH.D.

Catherine Limperopoulos, Ph.D., is the founding Director of the Developing Brain Institute and Director of the Advanced Pediatric Brain Imaging Research Program at Children’s National Hospital and Professor of Neurology, Radiology and Pediatrics at the George Washington University School of Medicine & Health Sciences.

The Developing Brain Institute has assembled leading scientists and health care providers from across myriad disciplines and health care models (tertiary care to primary care) at that are at the forefront of clinical research and translational efforts focused on accelerating screening, diagnosing, treating and preventing prenatal onset brain disorders to improve child health and well-being for life. Dr. Limperopoulos’ research seeks to understand the impact of an adverse intra- and extra-uterine environment on the developing fetal brain and its long-term neurodevelopmental repercussions. She is an occupational therapist and pediatric neuroscientist who has demonstrated repeated successes in completing novel patient-centered clinical and translational research in healthy and high-risk pregnant women and neurodiagnostic and neurodevelopmental surveillance in high-risk fetuses and preterm infants. She has or has had funding from the National Institutes of Health, Canadian Institutes of Health Research, the Department of Defense, the Centers for Disease Control and Prevention and private foundations, like the A. James & Alice B. Clark Foundation. She has authored more than 140 peer-reviewed publications. She also leads the Integrating Special Populations Module of the CNMC-GW NIH Clinical and Translational Science Award, which focuses on improving recruitment and retention of disadvantaged women into preventative maternal-fetal clinical trials aimed at optimizing long-term, maternal-infant health and well-being. She co-leads the DC Mother-Baby Wellness Network, funded by a June 2020 investment from the A. James & Alice B. Clark Foundation. The Network is a city-wide effort to create new interventions to reduce mental health issues commonly experienced by pregnant, low-income women.

Dr. Limperopoulos is founder and director of the DC Perinatal Mental Health Consortium, which brings together multiple stakeholders from our regional (Washington, D.C.) health care partners in obstetrics, psychiatry and pediatrics and an established community advisory board with representation of stakeholders from low-income, African American communities including DC-Primary Care Association, Mary’s Center, Community of Hope, Unity Health, DC-Primary care center, Mamatoto Village and African American patients, representatives with expertise in advocacy and policy. The overarching mission of this DC collaborative is to determine the optimal delivery of screening and low-cost interventions aimed at reducing the striking health disparities experienced by low-income women in the District of Columbia.



Profile

Address: 111 Michigan Ave NW, Washington, DC 20010
Department: MRI Lab

Recent Publications & Presentations


2021 | August
Brossard-Racine M, Limperopoulos C.
Cerebellar injury in premature neonates: Imaging findings and relationship with outcome. Semin Perinatol. 2021 Aug 21:151470. doi: 10.1016/j.semperi.2021.151470. Epub ahead of print. PMID: 34462245. https://pubmed.ncbi.nlm.nih.gov/34462025/
2021
Wu Y, Andescavage N, Lopez C, Quistorff JL, Donofrio MT, du Plessis AJ, Limperopoulos C.
Maternal mental distress and cortisol levels in pregnancies with congenital heart disease. Cardiol Young. 2021 Aug 31:1-5. doi: 10.1017/S1047951121003504. Epub ahead of print. PMID: 34462025. https://pubmed.ncbi.nlm.nih.gov/34462025/
2021
De Asis-Cruz, J, Barnett, S.D., Kim, J.H. and Limperopoulos, C.
Functional Connectivity-Derived Optimal Gestational-Age Cut Points for Fetal Brain Network Maturity
11(7), p.921.2021. https://www.mdpi.com
2021
Ottolini KM, Andescavage N, Kapse K, Jacobs M, Murnick J, VanderVeer R, Basu S, Said M, Limperopoulos C
Early lipid intake improves cerebellar growth in very low-birth-weight preterm infants.
JPEN J Parenter Enteral Nutr. 2021 Mar;45(3):587-595. doi: 10.1002/jpen.1868. Epub 2020 Jun 4. PMID: 32384168. https://pubmed.ncbi.nlm.nih.gov/32384168/
2021
De Asis-Cruz J, Andersen N, Kapse K, Khrisnamurthy D, Quistorff J, Lopez C, Vezina G, Limperopoulos C
Global Network Organization of the Fetal Functional Connectome.
Cereb Cortex. 2021 May 10;31(6):3034-3046. doi: 10.1093/cercor/bhaa410. PMID: 33558873; PMCID: PMC8107792. https://pubmed.ncbi.nlm.nih.gov/33558873/
2021
De Asis-Cruz J and Limperopoulos C.
Chapter 24 - Linking congenital heart disease and brain functional connectivity in newborns.
In Martin CR, Preedy VR, Rajendram R, eds. Diagnosis, Management and Modeling of Neurodevelopmental Disorders: Academic Press; 2021: 275-284. ISBN 9780128179888 https://www.sciencedirect.com/
2021
Gold S, Kapse K, Lopez C, Quistorff J, Downs S, Iqbal S, Limperopoulos C, Andescavage N. In vivo placental function in pregnancies complicated by maternal diabetes mellitus. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
2021
Andescavage N, Kushal K, Lu Y-C, Barnett S, Saeed H, Quistorff J, Lopez C, Limperopoulos C In-vivo changes of placental development during the COVID19 pandemic. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
2021
De Asis-Cruz J, Lopez C, Kapse K, Quistorff J, Vezina G, Donofrio M, Limperopoulos C In-utero MRI identifies altered resting state networks in fetuses with complex congenital heart disease. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
2021
Lu Y-C, Andescavage N, Saeed H, Quistorff J, Lopez C, Henderson D, Kapse K, Vezina G, du Plessis AJ, Limperopoulos C Structural changes of the human fetal brain during the COVID-19 pandemic. Society for Pediatric Research (SPR) Plenary Series: Best of SPR Featured Abstracts. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
2021
Ahmadzia HK, Lu Y-C, Barak S, Quistorff J, Lopez C, Kapse K, Limperopoulos C, Andescavage N Optimizing abnormal placentation detection prenatally using quantitative MRI. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
2021
Cook KM, De Asis-Cruz J, Lopez C, Quistorff J, Kapse K, Andresen N, Vezina G, Limperopoulos C In utero MRI differentiates male and female human fetal brain functional connectivity. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 3, 2021.
2021
Andescavage N, Bullen T, Liggett M, Barnett S, Espinosa K, Kapse A, Kapse K, Ahmadzia H, Quistorff J, Lopez C, Limperopoulos C Relating fetal brain development and neonatal neurobehavior in pregnancies complicated by fetal growth restriction. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 3, 2021.
2021
Lu Y-C, Andescavage N, Saeed H, Kapse K, Andersen N, Lopez C, Henderson D, Bulas D, du Plessis AJ, Limperopoulos C Influence of the COVID-19 pandemic on human placental morphology and texture. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 3, 2021.
2021
Pradhan S, Niforatos-Andescavage N, Saeed H, Barnett S, Kapse K, Andersen N, Quistorff J, Lopez C, Vezina G, Limperopoulos C Impaired fetal brain metabolism in pregnancies complicated by elevated maternal stress during the COVID-19 pandemic. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 2, 2021.
2021
Basu S, Kapse K, Espinosa K, Kapse A, Norman S, Fischer D, Barnett S, Andescavage N, Limperopoulos C Relationship of postnatal medications with regional brain volume and cognition-neurobehavior. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 2, 2021.
2021
Lu Y-C, Andescavage N, Kapse K, Andersen N, Lopez C, Quistorff J, Henderson D, Bulas D, Krishnan A, Donofrio MT, du Plessis AJ, Limperopoulos C Maternal anxiety alters in vivo placental morphology and texture in pregnancies complicated by fetal congenital heart disease. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 1, 2021.
2021
Basu S, Espinosa K, Pradhan S, Kapse K, De-Asis Cruz J, Kapse A, Norman S, Fischer D, Andescavage N, Limperopoulos C Cerebellar structure, function and neurodevelopmental outcomes in very preterm infants. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
2021
Schlatterer SD, Govindan RB, Murnick J, Barnett SD, Lopez C, Al-Shargabi T, Donofrio MT, Mulkey SB, Limperopoulos C, du Plessis AJ. Early heart rate variability correlates with pre-operative brain injury score in infants with congenital heart disease. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
2021
Pradhan S, Kapse K, Niforatos-Andescavage N, Quistorff J, Lopez C, Limperopoulos C. Increased brain lactate in fetuses of pregnant women with diabetes. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
2021
Andescavage N, Liggett M, Barnett S, Espinosa K, Kapse A, Kapse K, Ahmadzia H, Quistorff J, Lopez C, Limperopoulos C. Impaired prenatal cerebellar growth predicts neurodevelopmental outcomes in growth restricted fetuses. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
2021
Lopez, C, Quistorff J, Saeed H, Barnett S, Henderson D, Andescavage N, Limperopoulos C. Changes in psychological distress profiles in Hispanic and African American women before and during the COVID-19 pandemic. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
2021
Axel Largent PhD, Kushal Kapse MS, Scott D. Barnett PhD, Josepheen De Asis‐Cruz MD, PhD, Matthew Whitehead MD, Jonathan Murnick MD, PhD, Li Zhao PhD, Nicole Andersen BA, Jessica Quistorff MPH, Catherine Lopez MS, Catherine Limperopoulos PhD
Image Quality Assessment of Fetal Brain MRI Using Multi‐Instance Deep Learning Methods
[published online ahead of print, 2021 Apr 23]. J Magn Reson Imaging 2021 Apr 23. doi: 10.1002/jmri.27649. https://onlinelibrary.wiley.com
2021
Zun Z, Kapse K, Jacobs M, Basu S, Said M, Andersen N, Murnick J, Chang T, du Plessis A, Limperopoulos C.
Longitudinal Trajectories of Regional Cerebral Blood Flow in Very Preterm Infants during Third Trimester Ex Utero Development Assessed with MRI. Radiology. 2021 Mar 30:202423. doi: 10.1148/radiol.2021202423. Epub ahead of print. PMID: 33787337. https://pubmed.ncbi.nlm.nih.gov/33787337/
2021
Lu YC, Kapse K, Andersen N, Quistorff J, Lopez C, Fry A, Cheng J, Andescavage N, Wu Y, Espinosa K, Vezina G, du Plessis A, Limperopoulos C.
Association between socioeconomic status and in utero fetal brain development. JAMA Network Open. Published 2021, Mar 1;4(3):e213526. doi: 10.1001/jamanetworkopen.2021.3526. PMID: 33779746. https://pubmed.ncbi.nlm.nih.gov/33779746/
2020
De Asis-Cruz J, Krishnamurthy D, Zhao L, Kapse K, Vezina G, Andescavage N, Quistorff J, Lopez C, Limperopoulos C.
Association of prenatal maternal anxiety with fetal regional brain connectivity JAMA Network Open. Published 2020, Dec. 7;3(12):e2022349. doi:10.1001/jamanetworkopen.2020.22349 https://pubmed.ncbi.nlm.nih.gov/33284334/
2020
De Asis-Cruz J, Kapse K, Basu SK, Said M, Scheinost D, Murnick J, Chang T, du Plessis A, Limperopoulos C.
Functional brain connectivity in ex utero premature infants compared to in utero fetuses
[published online ahead of print, 2020 Jun 11]. Neuroimage. 2020;219:117043. doi:10.1016/j.neuroimage.2020.117043 https://pubmed.ncbi.nlm.nih.gov/32534962/
2020
Ottolini KM, Andescavage N, Kapse K, Jacobs M, Murnick J, VanderVeer R, Basu S, Said M, Limperopoulos C.
Early lipid intake improves cerebellar growth in very low-birth-weight preterm infants
[published online ahead of print, 2020 May 8]. JPEN J Parenter Enteral Nutr. 2020;10.1002/jpen.1868. doi:10.1002/jpen.1868 https://pubmed.ncbi.nlm.nih.gov/32384168/
2020
Andescavage N, You W, Jacobs M, Kapse K, Quistorff J, Bulas D, Ahmadzia H, Gimovsky A, Baschat A, Limperopoulos C.
Exploring in vivo placental microstructure in healthy and growth-restricted pregnancies through diffusion-weighted magnetic resonance imaging. Placenta.2020 Apr;93:113-118. doi: 10.1016/j.placenta.2020.03.004. Epub 2020 Mar 6. https://pubmed.ncbi.nlm.nih.gov/32250735/
2020
Wu Y, Stoodley C, Brossard-Racine M, Kapse K, Vezina G, Murnick J, du Plessis, AJ, Limperopoulos C.
Altered local cerebellar and brainstem development in preterm infants. Neuroimage. 2020 Jun;213:116702. doi: 10.1016/j.neuroimage.2020.116702. Epub 2020 Mar 5. https://pubmed.ncbi.nlm.nih.gov/32147366/
2020
Fumagalli M, Parodi A, Ramenghi L, Limperopoulos C, Steggerda S.
Ultrasound of acquired posterior fossa abnormalities in the newborn. Pediatric Research. 2020 Mar;87 (Supple 1):25-36. doi: 10.1038/s41390-020-0778-9. PMID: 32218537. https://pubmed.ncbi.nlm.nih.gov/32218537/
2020
Wu Y, Lu YC, Jacobs M, Pradhan S, Kapse K, Zhao L, Andescavage N, Vezina G, du Plessis A, Limperopoulos C.
Association of prenatal maternal psychological distress with fetal brain growth, metabolism, and cortical maturation. JAMA Network Open. 2020 Jan 3;3(1):e1919940. doi: 10.1001/jamanetworkopen.2019.19940. PMC6991285 https://pubmed.ncbi.nlm.nih.gov/31995213/
2019
Wu Y, Kapse K, Jacobs M, Andescavage N, Donofrio MT, Krishnan A, Vezina G, Wessel D, du Plessis A, Limperopoulos C.
Association of maternal psychological distress with in utero brain development in fetuses with congenital heart disease. JAMA Pediatrics. 2020 Jan 13; doi:10.1001/jamapediatrics.2019.5316 PMCID: PMC6990726 https://pubmed.ncbi.nlm.nih.gov/31930365/
2020
Ottolini KM, Andescavage N, Kapse K, Jacobs M, Limperopoulos C.
Improved brain growth and microstructural development in breast milk-fed very low birth weight premature infants. Acta Paediatrica. 2020 Jan 10. doi: 10.1111/apa.15168. [Epub ahead of print] https://pubmed.ncbi.nlm.nih.gov/31922288/
2020
You W, Andescavage N, Kapse K, Donofrio MT, Jacobs M, Limperopoulos C.
Hemodynamic responses of the placenta and brain to maternal hyperoxia in fetuses with congenital heart disease by using Blood Oxygen–Level Dependent MRI. Radiology 2020 Jan; 294(1):141-148. doi: 10.1148/radiol.2019190751. Epub 2019 Nov 5. https://pubmed.ncbi.nlm.nih.gov/31687920/
2019
Bouyssi-Kobar M, De Asis-Cruz J, Murnick J, Chang T, Limperopoulos C.
Altered functional brain network integration, segregation and modularity in very preterm infants at term equivalent age. Journal of Pediatrics 2019;213:13-21.e1. doi:10.1016/j.jpeds.2019.06.030 https://pubmed.ncbi.nlm.nih.gov/31358292/
2019
Ottolini KM, Andescavage N, Keller S, Limperopoulos C.
Nutrition and the developing brain: the road to optimizing early neurodevelopment: a systematic review. Pediatric Research. 2019 Jul 26. doi: 10.1038/s41390-019-0508-3. [Epub ahead of print] PMID: 31349359 https://pubmed.ncbi.nlm.nih.gov/31349359/
2019
Andescavage N, Dahdouh S, Jacobs M, Yewale S, Bulas D, Iqbal S, Baschat A, Limperopoulos C.
In vivo textural and morphometric analysis of placental development in healthy & growth-restricted pregnancies using magnetic resonance imaging. Pediatrics Research. 2019 Jun 25; 85(7):974-81. doi: 10.1038/s41390-019-0311-1. Epub 2019 Jan 25. PMCID: PMC6531319 https://pubmed.ncbi.nlm.nih.gov/30700836/
2019
Schlatterer SD, Murnick J, Jacobs M, White L, Donofrio MT, Limperopoulos C.
Placental pathology and neuroimaging correlates in neonates with congenital heart disease. Scientific Reports. 2019 Mar 11;9(1):4137. doi: 10.1038/s41598-019-40894-y. PMCID: PMC6411739 https://pubmed.ncbi.nlm.nih.gov/30858514/
2019
Basu S, Pradhan S, Kapse K, McCarter R, Murnick J, Chang T, Limperopoulos C.
Third trimester cerebellar metabolite concentrations are decreased in very premature infants with structural injury. Scientific Reports. 2019 Feb 4;9(1):1212. doi: 10.1038/s41598-018-37203-4. https://pubmed.ncbi.nlm.nih.gov/30718546/
2019
You W, Andescavage N, Kapse K, Donofrio M, Jacobs M, Limperopoulos C.
Altered hemodynamic responses of the placenta and fetal brain to maternal hyperoxia in the fetus with congenital heart disease. Circulation. 2019 Jan 10. (Accepted)
2019
Brossard-Racine M, McCarter R, Murnick J, Tinkelman L, Vezina G, Limperopoulos C.
Early extra-uterine exposure alters regional cerebellar growth in infants born preterm. NeuroImage: Clinical. 2019;21:101646. doi: 10.1016/j.nicl.2018.101646. Epub 2018 Dec 19 https://pubmed.ncbi.nlm.nih.gov/30630759/
2019
Krishnan A, Tague L, Rudra H, Pradhan S, Vezina G, Limperopoulos C.
Clinical course of a fetus with hypoplastic left heart syndrome and premature ductal constriction. Cardiol Young. 2018 Dec 27:1-3. doi: 10.1017/S1047951118001701. [Epub ahead of print] https://pubmed.ncbi.nlm.nih.gov/30587271/
2018
Hernandez-Castillo C, Limperopoulos C, Diedrichsen J.
A representative template of the neonatal cerebellum. NeuroImage. 2018 Sep 19;184:450-454. doi: 10.1016/j.neuroimage.2018.09.048. PMID 30243975 https://pubmed.ncbi.nlm.nih.gov/30243975/
2018
You W, Xu F, Limperopoulos C.
Linear convolution model of fetal circulation for hemodynamic responses to maternal hyperoxia using in utero functional MRI. Biomedical Imaging (ISBI 2018), 2018 IEEE 15th International Symposium on Biomedical Imaging. 2018 Apr;2018:1284-7. doi: 10.1109/ISBI.2018.8363806 https://pubmed.ncbi.nlm.nih.gov/29899816/
2018
Bouyssi-Kobar M, Brossard-Racine M, Jacobs M, Murnick J, Chang T, Limperopoulos C.
Regional microstructural organization of the cerebral cortex is affected by preterm birth. NeuroImage:Clinical. 2018;18:871-880. doi: 10.1016/j.nicl.2018.03.020 https://pubmed.ncbi.nlm.nih.gov/29876271/
2018
Mahdi E, Murnick J, Limperopoulos C.
Cerebral perfusion is perturbed by preterm birth and brain injury. American Journal of Neuroradiology. 2018; 39(7):1330-1335. PMID: 2974820 https://pubmed.ncbi.nlm.nih.gov/29748205/
2018
Zun Z, Limperopoulos C.
Placental perfusion imaging using velocity selective arterial spin labeling. Magnetic Resonance in Medicine. 2018 Sep;80(3):1036-1047. PMID:29436733 https://pubmed.ncbi.nlm.nih.gov/29436733/