Taeun Chang, M.D.

Director, Neonatal Neurology and Neurocritical Care Program

Taeun Chang, M.D., is Director of the Neonatal Neurology and Neurocritical Care Program at Children’s National Hospital and a Professor of Neurology and Pediatrics at the George Washington University School of Medicine & Health Sciences. Dr. Chang joined Children’s National in 2003 after completing her pediatric training at the Children’s Hospital of Pittsburgh and her child neurology fellowship at Children’s National. In 2004, she created the neonatal neurocritical care service, the second such program in the country and the only one in the District of Columbia region. The program now employs seven neonatal neurologists, the largest in the world. The program consults on one out of every three neonatal intensive care unit patients; has given therapeutic cooling to over 500 newborns since 2006; developed neonatal protocols for neuromonitoring, neuroimaging, brain injury, seizures & epilepsy and hemimegalencephaly; and provides subspecialty clinics for neonatal epilepsy, neonatal neurology and perinatal brain injury. Dr. Chang is active in national organizations or study groups in establishing electroencephalogram guidelines, seizure trials and neuroprotective therapies specific for newborns. She has published over 90 scientific articles and book chapters. Her research activities include neonatal EEG, neonatal seizures & epilepsy, placental and neurodisabilities, functional embolization, and neuroprotective clinical trials. Her mission is to advocate and expand clinical and translational research in prenatal-neonatal brain injury and neonatal neurotherapeutics.

Neonatal Neurology and Neonatal Neurocritical Care Program

Address: 111 Michigan Ave NW, Washington, DC 20010
Email: fetalbrain@childrensnational.org
Department: MRI Lab

Recent Publications & Presentations

Zun Z, Kapse K, Jacobs M, Basu S, Said M, Andersen N, Murnick J, Chang T, du Plessis A, Limperopoulos C.
Longitudinal Trajectories of Regional Cerebral Blood Flow in Very Preterm Infants during Third Trimester Ex Utero Development Assessed with MRI. Radiology. 2021 Mar 30:202423. doi: 10.1148/radiol.2021202423. Epub ahead of print. PMID: 33787337. https://pubmed.ncbi.nlm.nih.gov/33787337/
Basu SK, Pradhan S, Jacobs MB, Said M, Kapse K, Murnick J, Whitehead M, Chang T, du Plessis A, Limperopoulos C
Age and sex influences gamma-aminobutyric acid concentrations in the developing brain of very premature infants
Scientific Reports. 2020;10(1):10549. Published 2020 Jun 29. doi:10.1038/s41598-020-67188-y https://pubmed.ncbi.nlm.nih.gov/32601466/
De Asis-Cruz J, Kapse K, Basu SK, Said M, Scheinost D, Murnick J, Chang T, du Plessis A, Limperopoulos C
Functional brain connectivity in ex utero premature infants compared to in utero fetuses
[published online ahead of print, 2020 Jun 11]. Neuroimage. 2020;219:117043. doi:10.1016/j.neuroimage.2020.117043 https://pubmed.ncbi.nlm.nih.gov/32534962/
Lemmon M, Glass H, Shellhaas RA, Barks MC, Bailey B, Grant K, Grossbauer L, Pawlowski K, Wusthoff CJ, Chang T, Soul JS, Chu CJ, Thomas C, Massey SL, Abend NS, Rogers EE, Franck LS
Parent experience of caring for neonates with seizures
[published online ahead of print, 2020 Jun 5]. Arch Dis Child Fetal Neonatal Ed. 2020;fetalneonatal-2019-318612. doi:10.1136/archdischild-2019-318612 https://pubmed.ncbi.nlm.nih.gov/32503792/
Franck LS, Shellhaas RA, Lemmon ME, Sturza J, Soul JS, Chang T, Wusthoff CJ, Chu CJ, Massey SL, Abend NS, Thomas C, Rogers EE, McCulloch CE, Grant K, Grossbauerg L, Pawlowski K, Glass HC
Associations between infant and parent characteristics and measures of family well-being in neonates with seizures: A cohort study
Journal of Pediatrics. 2020;221:64-71.e4. doi:10.1016/j.jpeds.2020.02.024 https://pubmed.ncbi.nlm.nih.gov/32446494/
Kota S, Massaro AN, Chang T, Al-Shargabi T, Cristane C, Vezina LG, du Plessis A, Govindan RB
Prognostic value of continuous electroencephalogram delta power in neonates with hypoxic-ischemic encephalopathy
J Child Neurology. 2020;35(8):517-525. doi:10.1177/0883073820915323 https://pubmed.ncbi.nlm.nih.gov/32306827/
Wu YW, Goodman AM, Chang T, Mulkey SB, Gonzalez FF, Mayock DE, Juul SE, Mathur AM, Van Meurs K, McKinstry RC, Redline RW
Placental pathology and neonatal brain MRI in a randomized trial of erythropoietin for hypoxic-ischemic encephalopathy
Pediatric Research. 2020;87(5):879-884. doi:10.1038/s41390-019-0493-6 https://pubmed.ncbi.nlm.nih.gov/31261373/
Massaro AN, Wu YW, Bammler TK, MacDonald JW, Mathur A, Chang T, Mayock D, Mulkey SB, van Meurs K, Afsharinejad Z, Juul S
Dried blood spot compared to plasma measurements of blood-based biomarkers of brain injury in neonatal encephalopathy
Pediatric Research. 2019;85(5):655-661. doi:10.1038/s41390-019-0298-7 https://pubmed.ncbi.nlm.nih.gov/30661082/
Bouyssi-Kobar M, De Asis-Cruz J, Murnick J, Chang T, Limperopoulos C
Altered functional brain network integration, segregation and modularity in very preterm infants at term equivalent age
Journal of Pediatrics. 2019;213:13-21.e1. doi:10.1016/j.jpeds.2019.06.030 https://pubmed.ncbi.nlm.nih.gov/31358292/
Glass HC, Soul JS, Chu CJ, Massey SL, Wusthoff CJ, Chang T, Cilio MR, Bonifacio SL, Abend NS, Thomas C, Lemmon M, McCulloch CE, Shellhaas RA
Response to antiseizure medications in neonates with acute symptomatic seizures
Epilepsia. 2019;60(3):e20-e24. doi:10.1111/epi.14671 https://pubmed.ncbi.nlm.nih.gov/30790268/
Obeid R, Tabrizi PR, Mansoor A, Cerrolaza JJ, Chang T, Penn AA, Linguraru MG
Ventricular shape evaluation on early ultrasound predicts post-hemorrhagic hydrocephalus
Pediatric Research. 2019;85(3):293-298. doi:10.1038/s41390-018-0252-0 https://pubmed.ncbi.nlm.nih.gov/30631137/
Reich DA, Govindan RB, Whitehead MT, et al. Wang J, Chang, T, du Plessis A
The effect of unilateral stroke on autonomic function in the term newborn
Pediatric Research. 2019;85(6):830-834. doi:10.1038/s41390-019-0320-0 https://pubmed.ncbi.nlm.nih.gov/30712058/
Basu S, Pradhan S, Kapse K, McCarter R, Murnick J, Chang T, Limperopoulos C
Third trimester cerebellar metabolite concentrations are decreased in very premature infants with structural injury
Scientific Reports. 2019 Feb 4;9(1):1212. doi: 10.1038/s41598-018-37203-4. https://pubmed.ncbi.nlm.nih.gov/30718546/
Govindan RB, Massaro A, Vezina G, Chang T, du Plessis A
Identifying an optimal epoch length for spectral analysis of heart rate of critically-ill infants
Comput Biol Med. 2019;113:103391. doi:10.1016/j.compbiomed.2019.103391 https://pubmed.ncbi.nlm.nih.gov/31446320/
Bouyssi-Kobar M, Brossard-Racine M, Jacobs M, Murnick J, Chang T, Limperopoulos C
Regional microstructural organization of the cerebral cortex is affected by preterm birth
NeuroImage:Clinical. 2018;18:871-880.Doi: 10.1016/j.nicl.2018.03.020 https://pubmed.ncbi.nlm.nih.gov/29876271/