Steve C.N. Hui, Ph.D.

Research Faculty (Assistant Professor)

Steve C.N. Hui, Ph.D., is a research faculty (assistant professor) in the Developing Brain Institute (DBI) at Children’s National Hospital. Steve’s research interests lie in the application and development of new sequences for brain magnetic resonance (MR) spectroscopy.

Prior joining DBI, he completed his postdoctoral fellowship at the Johns Hopkins University School of Medicine. Steve has participated in the HEALthy Brain and Child Development (HBCD) study, a large National Institutes of Health-funded study of early-childhood brain development involving 25 sites around the U.S. He also was involved in other collaborative studies, including the investigation of frequency drift, which included 80 participating sites, using over 100 3T MR scanners from three major vendors; and another study that investigated the relationship between age and macromolecular concentrations. Steve also has developed the MRSCloud, a cloud-based platform for generating metabolite basis sets for linear-combination modeling analyses, which aims to help community users to acquire basis sets in a reliable and convenient manner.

Steve completed his M.Sc. and Ph.D. studies at the Chinese University of Hong Kong. During his postgraduate training, he focused on the development of an automated algorithm for lipid segmentation using MR imaging, and he studied the etiology of non-alcoholic fatty liver disease using MR spectroscopy. He obtained his bachelor’s degree in Applied Science at the University of British Columbia.

Address: 111 Michigan Ave NW, Washington, DC 20010
Email: fetalbrain@childrensnational.org
Department: MRI Lab

Recent Publications & Presentations

Li N, Ma W, Ren F, Li X, Li F, Zong W, Wu L, Dai Z, Hui SCN, Edden RAE, Li M, Gao F.
Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis. Neuroimage. 2023 Mar;268:119861. doi: 10.1016/j.neuroimage.2023.119861. Epub 2023 Jan 5. PMID: 36610677; PMCID: PMC10026366
Hupfeld KE, Zöllner HJ, Oeltzschner G, Hyatt HW, Herrmann O, Gallegos J, Hui SCN, Harris AD, Edden RAE, Tsapkini K.
Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity. Neurobiol Aging. 2023 Feb;122:65-75. doi: 10.1016/j.neurobiolaging.2022.11.006. Epub 2022 Nov 17. PMID: 36508896; PMCID: PMC9839619
Gong T, Hui SCN, Zöllner HJ, Britton M, Song Y, Chen Y, Gudmundson AT, Hupfeld KE, Davies-Jenkins CW, Murali-Manohar S, Porges EC, Oeltzschner G, Chen W, Wang G, Edden RAE.
Neurometabolic timecourse of healthy aging. Neuroimage. 2022 Dec 1;264:119740. doi: 10.1016/j.neuroimage.2022.119740. Epub 2022 Nov 8. PMID: 36356822; PMCID: PMC9902072
Zöllner HJ, Davies-Jenkins CW, Murali-Manohar S, Gong T, Hui SCN, Song Y, Chen W, Wang G, Edden RAE, Oeltzschner G.
Feasibility and implications of using subject-specific macromolecular spectra to model short echo time magnetic resonance spectroscopy data. NMR Biomed. 2023 Mar;36(3):e4854. doi: 10.1002/nbm.4854. Epub 2022 Nov 14. PMID: 36271899; PMCID: PMC9930668
Lacroix A, Proteau-Lemieux M, Côté S, Near J, Hui SCN, Edden RAE, Lippé S, Çaku A, Corbin F, Lepage JF.
Multimodal assessment of the GABA system in patients with fragile-X syndrome and neurofibromatosis of type 1. Neurobiol Dis. 2022 Nov;174:105881. doi: 10.1016/j.nbd.2022.105881. Epub 2022 Oct 3. PMID: 36202290
Song Y, Zöllner HJ, Hui SCN, Hupfeld KE, Oeltzschner G, Edden RAE.
Impact of gradient scheme and non-linear shimming on out-of-voxel echo artifacts in edited MRS. NMR Biomed. 2023 Feb;36(2):e4839. doi: 10.1002/nbm.4839. Epub 2022 Oct 19. PMID: 36196802; PMCID: PMC9845189 https://pubmed.ncbi.nlm.nih.gov/36196802/
Hui SCN, Saleh MG, Zöllner HJ, Oeltzschner G, Fan H, Li Y, Song Y, Jiang H, Near J, Lu H, Mori S, Edden RAE.
MRSCloud: A cloud-based MRS tool for basis set simulation. Magn Reson Med. 2022 Nov;88(5):1994-2004. doi: 10.1002/mrm.29370. Epub 2022 Jul 1. PMID: 35775808; PMCID: PMC9420769 https://pubmed.ncbi.nlm.nih.gov/35775808/
Song Y, Zöllner HJ, Hui SCN, Hupfeld K, Oeltzschner G, Prisciandaro JJ, Edden R.
Importance of Linear Combination Modeling for Quantification of Glutathione and γ-Aminobutyric Acid Levels Using Hadamard-Edited Magnetic Resonance Spectroscopy. Front Psychiatry. 2022 Apr 25;13:872403. doi: 10.3389/fpsyt.2022.872403. PMID: 35546940; PMCID: PMC9082488
Hui SCN, Gong T, Zöllner HJ, Song Y, Murali-Manohar S, Oeltzschner G, Mikkelsen M, Tapper S, Chen Y, Saleh MG, Porges EC, Chen W, Wang G, Edden RAE.
The macromolecular MR spectrum does not change with healthy aging. Magn Reson Med. 2022 Apr;87(4):1711-1719. doi: 10.1002/mrm.29093. Epub 2021 Nov 28. PMID: 34841564; PMCID: PMC8935352 https://pubmed.ncbi.nlm.nih.gov/34841564/
Song Y, Lally PJ, Yanez Lopez M, Oeltzschner G, Nebel MB, Gagoski B, Kecskemeti S, Hui SCN, Zöllner HJ, Shukla D, Arichi T, De Vita E, Yedavalli V, Thayyil S, Fallin D, Dean DC 3rd, Grant PE, Wisnowski JL, Edden RAE.
Edited magnetic resonance spectroscopy in the neonatal brain. Neuroradiology. 2022 Feb;64(2):217-232. doi: 10.1007/s00234-021-02821-9. Epub 2021 Oct 15. PMID: 34654960; PMCID: PMC8887832 https://pubmed.ncbi.nlm.nih.gov/34654960/
Zöllner HJ, Tapper S, Hui SCN, Barker PB, Edden RAE, Oeltzschner G.
Comparison of linear combination modeling strategies for edited magnetic resonance spectroscopy at 3 T. NMR Biomed. 2022 Jan;35(1):e4618. doi: 10.1002/nbm.4618. Epub 2021 Sep 23. PMID: 34558129; PMCID: PMC8935346 https://pubmed.ncbi.nlm.nih.gov/34558129/
Tapper S, Hui SCN, Saleh MG, Zöllner HJ, Oeltzschner G, Near J, Soher BJ, Edden RAE.
Influence of editing pulse flip angle on J-difference MR spectroscopy. Magn Reson Med. 2022 Feb;87(2):589-596. doi: 10.1002/mrm.29008. Epub 2021 Sep 14. PMID: 34520079; PMCID: PMC8627430 https://pubmed.ncbi.nlm.nih.gov/34520079/
Hui SCN, Zöllner HJ, Oeltzschner G, Edden RAE, Saleh MG.
In vivo spectral editing of phosphorylethanolamine. Magn Reson Med. 2022 Jan;87(1):50-56. doi: 10.1002/mrm.28976. Epub 2021 Aug 19. PMID: 34411324; PMCID: PMC8616810
Hui SCN, Mikkelsen M, Zöllner HJ, et al.
Frequency drift in MR spectroscopy at 3T. Neuroimage. 2021 Nov 1;241:118430. doi: 10.1016/j.neuroimage.2021.118430. Epub 2021 Jul 24. PMID: 34314848; PMCID: PMC8456751
Chiyanika C, Wong VW, Wong GL, Chan HL, Hui SCN, Yeung DKW, Chu WCW.
Implications of Abdominal Adipose Tissue Distribution on Nonalcoholic Fatty Liver Disease and Metabolic Syndrome: A Chinese General Population Study. Clin Transl Gastroenterol. 2021 Feb 17;12(2):e00300. doi: 10.14309/ctg.0000000000000300. PMID: 33600104; PMCID: PMC7889374
Zöllner HJ, Považan M, Hui SCN, Tapper S, Edden RAE, Oeltzschner G.
Comparison of different linear-combination modeling algorithms for short-TE proton spectra. NMR Biomed. 2021 Apr;34(4):e4482. doi: 10.1002/nbm.4482. Epub 2021 Feb 2. PMID: 33530131; PMCID: PMC8935349 https://pubmed.ncbi.nlm.nih.gov/33530131/