Rathinaswamy Bhavanandhan “R.B.” Govindan, Ph.D., MS

Director of the Advanced Physiological Signals Processing Laboratory

Rathinaswamy “R.B.” Bhavanandhan Govindan, Ph.D., MS, is director of the Advanced Physiological Signals Processing Laboratory (APSPL) at Children’s National Hospital, overseeing the acquisition of high-quality signals, developing and maintaining automated analyses pipelines for processing these signals, and training end-users on the application of these analyses pipelines. The primary goal of APSPL research is identifying antecedents of brain injury in critically ill infants through continuous monitoring and characterization of multimodal physiological signals. Dr. Govindan has experience in developing monitoring tools to acquire and process data from patients’ bedside monitors. Using proprietary software, his team has continuously collected electrocardiograms and processed heartrate variability in close to real-time for several days from 100+ infants. He also has experience in collecting and processing data using wearable sensors (e.g., Everion, Biofourmis, Boston, U.S.). Using Everion, Govindan’ team reliably has collected heart rates from nearly 200 pregnant women and mothers of newborns to understand the onset of pregnancy-related stress or postpartum depression. Dr. Govindan’s current research focus is on real-time characterization of the physiological signals to derive biomarkers that can help to make informed clinical decisions. His team has honed several signal processing routines to address the highly prevalent artifacts in the physiological signals collected in a hostile environment of critical care monitoring. He has served as a Co-investigator on several National Institutes of Health grants.

RB received his Ph.D. in biomedical signal processing from the Indian Institute of Technology, Madras, Chennai, India. Recently, he received an MS degree in Biotechnology with a specialization in Bioinformatics from the University of Maryland Global Campus.

Address: 111 Michigan Ave NW, Washington, DC 20010
Email: fetalbrain@childrensnational.org
Department: MRI Lab

Recent Publications & Presentations

Schlatterer SD, Govindan RB, Murnick J, Barnett SD, Lopez C, Donofrio MT, Mulkey SB, Limperopoulos C, du Plessis AJ
In infants with congenital heart disease autonomic dysfunction is associated with pre-operative brain injury Pediatr Res. 2021 Dec 28. doi: 10.1038/s41390-021-01931-7. Epub ahead of print. PMID: 34963700 https://pubmed.ncbi.nlm.nih.gov/34963700/
Massaro AN, Lee JK, Vezina G, Glass P, O'Kane A, Li R, Chang T, Brady K, Govindan R.
Global Exploratory Assessment of the Relationship Between Hemoglobin Volume Phase Index, Magnetic Resonance Imaging, and Functional Outcome in Neonates with Hypoxic-Ischemic Encephalopathy
Neurocrit Care. 2021 Aug;35(1):121-129. doi: 10.1007/s12028-020-01150-8. Epub 2020 Nov 20. PMID: 33215394; PMCID: PMC8134623. https://pubmed.ncbi.nlm.nih.gov/33215394/
Mulkey SB, Hitchings L, Persaud R, Kota S, Maxwell GL, Baker R, du Plessis A, Govindan R.
Cerebral cortical autonomic connectivity in low-risk term newborns. Clin Auton Res. 2021 Jun;31(3):415-424. doi: 10.1007/s10286-021-00793-7. Epub 2021 Mar 14. PMID: 33718981. https://pubmed.ncbi.nlm.nih.gov/33718981/ https://pubmed.ncbi.nlm.nih.gov/33718981/
Niepel D, Krishna B, Siegel ER, Draganova R, Preissl H, Govindan RB, Eswaran H.
A pilot study: Auditory steady-state responses (ASSR) can be measured in human fetuses using fetal magnetoencephalography (fMEG) PLoS One. 2020 Jul 22;15(7):e0235310. doi: 10.1371/journal.pone.0235310. PMID: 32697776; PMCID: PMC7375519. https://pubmed.ncbi.nlm.nih.gov/32697776/
Kota S, Massaro AN, Chang T, Al-Shargabi T, Cristane C, Vezina LG, du Plessis A, Govindan RB
Prognostic value of continuous electroencephalogram delta power in neonates with hypoxic-ischemic encephalopathy. J Child Neurology. 2020;35(8):517-525. doi:10.1177/0883073820915323 https://pubmed.ncbi.nlm.nih.gov/32306827/
Mulkey SB, Govindan RB, Hitchings L, Al-Shargabi T, Herrera N, Swisher CB, Eze A Jr, Russo S, Schlatterer SD, Jacobs MB, McCarter R, Kline A, Maxwell GL, Baker R, du Plessis AJ
Autonomic nervous system maturation in the premature extrauterine milieu. Pediatric Research. 2020 May 12. doi: 10.1038/s41390-020-0952-0. Epub ahead of print. PMID: 32396923 https://pubmed.ncbi.nlm.nih.gov/32396923/
Govindan V, Govindan R, Massaro AN, Al-Shargabi T, Andescavage NN, Vezina G, Murnick J, Wang Y, Metzler M, Cristante C, Swisher C, Reich D, Plessis AD
Cerebral venous volume changes and pressure autoregulation in critically ill infants. J Perinatol. 2020 May;40(5):806-811. doi: 10.1038/s41372-020-0626-0. Epub 2020 Mar 10. PMID: 32157219; PMCID: PMC7224055. https://pubmed.ncbi.nlm.nih.gov/32157219/
Mulkey SB, Govindan R, Metzler M, Swisher CB, Hitchings L, Wang Y, Baker R, Larry Maxwell G, Krishnan A, du Plessis AJ
Heart rate variability is depressed in the early transitional period for newborns with complex congenital heart disease. Clinical Autonomic Research. 2020 Apr;30(2):165-172. doi: 10.1007/s10286-019-00616-w. Epub 2019 Jun 25. PMID: 31240423; PMCID: PMC6930356. https://pubmed.ncbi.nlm.nih.gov/31240423/
Govindan RB
Detrended fluctuation analysis using orthogonal polynomials Phys Rev E. 2020 Jan;101(1-1):010201. doi: 10.1103/PhysRevE.101.010201. PMID: 32069526. https://pubmed.ncbi.nlm.nih.gov/32069526/