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Nickie Niforatos Andescavage, M.D.

Clinical Director, Developing Brain Institute; Attending, Neonatal-Perinatal Medicine; Director, Neonatal Transport

Nickie Niforatos Andescavage, M.D., is clinical director of the Developing Brain Institute (DBI) and in this role supports coordination of DBI’s prenatal and NICU studies, leads our community engagement efforts with obstetricians and maternal-fetal medicine specialists, and expands our clinical research enterprise to a growing number of community NICUs. Dr. Andescavage also is an attending physician in the Division of Neonatal-Perinatal Medicine at Children’s National; director of the Perinatal-Neonatal Program for the Prenatal Pediatrics Institute; and a tenure-track Assistant Professor of Pediatrics at the George Washington University School of Medicine & Health Sciences. Dr. Andescavage’s background in neonatology began with early academic interests in the mechanisms of acquired brain injury in premature infants. A subsequent fellowship in fetal medicine has provided her additional expertise in fetal brain development, including training in advanced structural imaging techniques. These sophisticated techniques allow for more rigorous study of the development and metabolism of the fetal brain, and the more precise detection of injury, as well as the role of placental development on fetal neurodevelopment. She is the Principal Investigator of an active Eunice Kennedy Shriver National Institute of Child Health and Human Development K23 career development grant, recipient of the District of Columbia Center for AIDS Research Pilot Award on advanced placental imaging in pregnant women living with HIV and a Co-Investigator on several research studies on mechanisms of acquired brain injury in the neonatal population.


Address: 111 Michigan Ave NW, Washington, DC 20010
Email: fetalbrain@childrensnational.org
Department: MRI Lab

Recent Publications & Presentations


2022 | April
Wu Y, Espinosa KM, Barnett SD, Kapse A, Quistorff JL, Lopez C, Andescavage N, Pradhan S, Lu YC, Kapse K, Henderson D, Vezina G, Wessel D, du Plessis AJ, Limperopoulos C.
Association of elevated maternal psychological distress, altered fetal brain, and offspring cognitive and social-emotional outcomes at 18 months. JAMA Netw Open. 2022 Apr 1;5(4):e229244. doi: 10.1001/jamanetworkopen.2022.9244. PMID: 35486403; PMCID: PMC9055453. https://pubmed.ncbi.nlm.nih.gov/35486403/
2022
Largent A, De Asis-Cruz J, Kapse K, Barnett SD, Murnick J, Basu S, Andersen N, Norman S, Andescavage N, Limperopoulos C.
Automatic brain segmentation in preterm infants with post-hemorrhagic hydrocephalus using 3D Bayesian U-Net Hum Brain Mapp. 2022 Jan 13. doi: 10.1002/hbm.25762. Epub ahead of print. PMID: 35023255 https://pubmed.ncbi.nlm.nih.gov/35023255/
2021
Wu Y, Lu YC, Kapse K, Jacobs M, Andescavage N, Donofrio MT, Lopez C, Quistorff JL, Vezina G, Krishnan A, du Plessis AJ, Limperopoulos C
In utero MRI identifies impaired second trimester subplate growth in fetuses with congenital heart disease
Cereb Cortex. 2021 Oct 28:bhab386. doi: 10.1093/cercor/bhab386. Epub ahead of print. PMID: 34882775 https://pubmed.ncbi.nlm.nih.gov/34882775/
2021
Andescavage N, Limperopoulos C.
Emerging placental biomarkers of health and disease through advanced magnetic resonance imaging (MRI)
Exp Neurol. 2021 Sep 22:113868. doi: 10.1016/j.expneurol.2021.113868. Epub ahead of print. PMID: 34562472. https://pubmed.ncbi.nlm.nih.gov/34562472/
2021
Wu Y, Andescavage N, Lopez C, Quistorff JL, Donofrio MT, du Plessis AJ, Limperopoulos C.
Maternal mental distress and cortisol levels in pregnancies with congenital heart disease. Cardiol Young. 2021 Aug 31:1-5. doi: 10.1017/S1047951121003504. Epub ahead of print. PMID: 34462025. https://pubmed.ncbi.nlm.nih.gov/34462025/
2021
Andescavage N, Kapse K, Lu YC, Barnett SD, Jacobs M, Gimovsky AC, Ahmadzia H, Quistorff J, Lopez C, Andersen NR, Bulas D, Limperopoulos C
Normative placental structure in pregnancy using quantitative Magnetic Resonance Imaging
Placenta. 2021 Jul 31;112:172-179. doi: 10.1016/j.placenta.2021.07.296. Epub ahead of print. PMID: 34365206. https://pubmed.ncbi.nlm.nih.gov/34365206/
2021
Ottolini KM, Andescavage N, Kapse K, Jacobs M, Murnick J, VanderVeer R, Basu S, Said M, Limperopoulos C
Early lipid intake improves cerebellar growth in very low-birth-weight preterm infants.
JPEN J Parenter Enteral Nutr. 2021 Mar;45(3):587-595. doi: 10.1002/jpen.1868. Epub 2020 Jun 4. PMID: 32384168. https://pubmed.ncbi.nlm.nih.gov/32384168/
2021
Gold S, Kapse K, Lopez C, Quistorff J, Downs S, Iqbal S, Limperopoulos C, Andescavage N. In vivo placental function in pregnancies complicated by maternal diabetes mellitus. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
2021
Andescavage N, Kushal K, Lu Y-C, Barnett S, Saeed H, Quistorff J, Lopez C, Limperopoulos C In-vivo changes of placental development during the COVID19 pandemic. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
2021
Lu Y-C, Andescavage N, Saeed H, Quistorff J, Lopez C, Henderson D, Kapse K, Vezina G, du Plessis AJ, Limperopoulos C Structural changes of the human fetal brain during the COVID-19 pandemic. Society for Pediatric Research (SPR) Plenary Series: Best of SPR Featured Abstracts. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
2021
Ahmadzia HK, Lu Y-C, Barak S, Quistorff J, Lopez C, Kapse K, Limperopoulos C, Andescavage N Optimizing abnormal placentation detection prenatally using quantitative MRI. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
2021
Andescavage N, Bullen T, Liggett M, Barnett S, Espinosa K, Kapse A, Kapse K, Ahmadzia H, Quistorff J, Lopez C, Limperopoulos C Relating fetal brain development and neonatal neurobehavior in pregnancies complicated by fetal growth restriction. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 3, 2021.
2021
Lu Y-C, Andescavage N, Saeed H, Kapse K, Andersen N, Lopez C, Henderson D, Bulas D, du Plessis AJ, Limperopoulos C Influence of the COVID-19 pandemic on human placental morphology and texture. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 3, 2021.
2021
Pradhan S, Niforatos-Andescavage N, Saeed H, Barnett S, Kapse K, Andersen N, Quistorff J, Lopez C, Vezina G, Limperopoulos C Impaired fetal brain metabolism in pregnancies complicated by elevated maternal stress during the COVID-19 pandemic. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 2, 2021.
2021
Basu S, Kapse K, Espinosa K, Kapse A, Norman S, Fischer D, Barnett S, Andescavage N, Limperopoulos C Relationship of postnatal medications with regional brain volume and cognition-neurobehavior. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 2, 2021.
2021
Lu Y-C, Andescavage N, Kapse K, Andersen N, Lopez C, Quistorff J, Henderson D, Bulas D, Krishnan A, Donofrio MT, du Plessis AJ, Limperopoulos C Maternal anxiety alters in vivo placental morphology and texture in pregnancies complicated by fetal congenital heart disease. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 1, 2021.
2021
Basu S, Espinosa K, Pradhan S, Kapse K, De-Asis Cruz J, Kapse A, Norman S, Fischer D, Andescavage N, Limperopoulos C Cerebellar structure, function and neurodevelopmental outcomes in very preterm infants. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
2021
Pradhan S, Kapse K, Niforatos-Andescavage N, Quistorff J, Lopez C, Limperopoulos C. Increased brain lactate in fetuses of pregnant women with diabetes. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
2021
Andescavage N, Liggett M, Barnett S, Espinosa K, Kapse A, Kapse K, Ahmadzia H, Quistorff J, Lopez C, Limperopoulos C. Impaired prenatal cerebellar growth predicts neurodevelopmental outcomes in growth restricted fetuses. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
2021
Lopez, C, Quistorff J, Saeed H, Barnett S, Henderson D, Andescavage N, Limperopoulos C. Changes in psychological distress profiles in Hispanic and African American women before and during the COVID-19 pandemic. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
2020
De Asis-Cruz J, Krishnamurthy D, Zhao L, Kapse K, Vezina G, Andescavage N, Quistorff J, Lopez C, Limperopoulos C.
Association of prenatal maternal anxiety with fetal regional brain connectivity JAMA Network Open. Published 2020, Dec. 7;3(12):e2022349. doi:10.1001/jamanetworkopen.2020.22349 https://pubmed.ncbi.nlm.nih.gov/33284334/
2020
Ottolini KM, Andescavage N, Kapse K, Jacobs M, Murnick J, VanderVeer R, Basu S, Said M, Limperopoulos C.
Early lipid intake improves cerebellar growth in very low-birth-weight preterm infants
[published online ahead of print, 2020 May 8]. JPEN J Parenter Enteral Nutr. 2020;10.1002/jpen.1868. doi:10.1002/jpen.1868 https://pubmed.ncbi.nlm.nih.gov/32384168/
2020
Basu SK, Pradhan S, Jacobs MB, Said M, Kapse K, Murnick J, Whitehead MT, Chang T, du Plessis AJ, Limperopoulos C.
Age and sex influences gamma-aminobutyric acid concentrations in the developing brain of very premature infants.
Sci Rep. 2020 Jun 29;10(1):10549. doi: 10.1038/s41598-020-67188-y.Sci Rep. 2020. PMID: 32601466 https://pubmed.ncbi.nlm.nih.gov/32601466/
2020
Andescavage N, You W, Jacobs M, Kapse K, Quistorff J, Bulas D, Ahmadzia H, Gimovsky A, Baschat A, Limperopoulos C.
Exploring in vivo placental microstructure in healthy and growthrestricted pregnancies through diffusion-weighted magnetic resonance imaging.
Placenta.2020 Apr;93:113-118. doi: 10.1016/j.placenta.2020.03.004. Epub 2020 Mar 6. https://pubmed.ncbi.nlm.nih.gov/32250735/
2020
Wu Y, Lu YC, Jacobs M, Pradhan S, Kapse K, Zhao L, Andescavage N, Vezina G, du Plessis A, Limperopoulos C.
Association of prenatal maternal psychological distress with fetal brain growth, metabolism, and cortical maturation.
JAMA Network Open. 2020 Jan 3;3(1):e1919940. doi: 10.1001/jamanetworkopen.2019.19940. PMC6991285 https://pubmed.ncbi.nlm.nih.gov/31995213/
2020
Wu Y, Kapse K, Jacobs M, Andescavage N, Donofrio MT, Krishnan A, Vezina G, Wessel D, du Plessis A, Limperopoulos C.
Association of maternal psychological distress with in utero brain development in fetuses with congenital heart disease.
JAMA Pediatrics. 2020 Jan 13; doi:10.1001/jamapediatrics.2019.5316 PMCID: PMC6990726 https://pubmed.ncbi.nlm.nih.gov/31930365/
2020
Ottolini KM, Andescavage N, Kapse K, Jacobs M, Limperopoulos C.
Improved brain growth and microstructural development in breast milk-fed very low birth weight premature infants.
Acta Paediatrica. 2020 Jan 10. doi: 10.1111/apa.15168. [Epub ahead of print] https://pubmed.ncbi.nlm.nih.gov/31922288/
2020
You W, Andescavage N, Kapse K, Donofrio MT, Jacobs M, Limperopoulos C.
Hemodynamic responses of the placenta and brain to maternal hyperoxia in fetuses with congenital heart disease by using Blood Oxygen–Level Dependent MRI.
Radiology 2020 Jan; 294(1):141-148. doi: 10.1148/radiol.2019190751. Epub 2019 Nov 5. https://pubmed.ncbi.nlm.nih.gov/31687920/
2019
Ottolini KM, Andescavage N, Keller S, Limperopoulos C.
Pediatric Research. 2019 Jul 26. doi: 10.1038/s41390-019-0508-3. [Epub ahead of print] PMID: 31349359
Radiology 2020 Jan; 294(1):141-148. doi: 10.1148/radiol.2019190751. Epub 2019 Nov 5. https://pubmed.ncbi.nlm.nih.gov/31349359/
2019
Andescavage N, Dahdouh S, Jacobs M, Yewale S, Bulas D, Iqbal S, Baschat A, Limperopoulos C.
In vivo textural and morphometric analysis of placental development in healthy & growth-restricted pregnancies using magnetic resonance imaging.
Pediatrics Research. 2019 Jun 25; 85(7):974-81. doi: 10.1038/s41390-019-0311-1. Epub 2019 Jan 25. PMCID: PMC6531319 https://pubmed.ncbi.nlm.nih.gov/30700836/
2019
You W, Andescavage N, Kapse K, Donofrio M, Jacobs M, Limperopoulos C.
Altered hemodynamic responses of the placenta and fetal brain to maternal hyperoxia in the fetus with congenital heart disease.
Circulation. 2019 Jan 10. (Accepted)