Mary T. Donofrio, M.D.

Medical Director, Prenatal Cardiology Program
Co-Director, Cardiac Neurodevelopmental Outcome Program

Mary T. Donofrio, M.D., Medical Director of the Prenatal Cardiology Program at Children’s National, is an international expert in fetal cardiology and has published over 100 papers, including the American Heart Association Scientific Statement on the Diagnosis and Treatment of Fetal Cardiac Disease. Dr. Donofrio is one of the founders and current president of the Fetal Heart Society, a non-profit organization created to advance the art and science of prenatal cardiovascular medicine; to improve the understanding of in-utero cardiovascular physiology by fostering scientific research, organized research collaboration and mentorship; and to educate medical and research professionals through scientific publications, education and meetings.

Address: 111 Michigan Ave NW, Washington, DC 20010
Email: fetalbrain@childrensnational.org
Department: MRI Lab

Recent Publications & Presentations

Schlatterer SD, Govindan RB, Murnick J, Barnett SD, Lopez C, Donofrio MT, Mulkey SB, Limperopoulos C, du Plessis AJ
In infants with congenital heart disease autonomic dysfunction is associated with pre-operative brain injury Pediatr Res. 2021 Dec 28. doi: 10.1038/s41390-021-01931-7. Epub ahead of print. PMID: 34963700 https://pubmed.ncbi.nlm.nih.gov/34963700/
Wu Y, Lu YC, Kapse K, Jacobs M, Andescavage N, Donofrio MT, Lopez C, Quistorff JL, Vezina G, Krishnan A, du Plessis AJ, Limperopoulos C
In utero MRI identifies impaired second trimester subplate growth in fetuses with congenital heart disease
Cereb Cortex. 2021 Oct 28:bhab386. doi: 10.1093/cercor/bhab386. Epub ahead of print. PMID: 34882775 https://pubmed.ncbi.nlm.nih.gov/34882775/
Espinosa KM, Julian M, Wu Y, Lopez C, Donofrio MT, Krishnan A, Goudar S, Bowers S, Douglas-Barnett S, Limperopoulos C, Le HN
"The Mental Health Piece is Huge": perspectives on developing a prenatal maternal psychological intervention for congenital heart disease
Cardiol Young. 2021 Sep 30:1-8. doi: 10.1017/S1047951121004030. Epub ahead of print. PMID: 34588092. https://pubmed.ncbi.nlm.nih.gov/34588092/
Wu Y, Andescavage N, Lopez C, Quistorff JL, Donofrio MT, du Plessis AJ, Limperopoulos C.
Maternal mental distress and cortisol levels in pregnancies with congenital heart disease. Cardiol Young. 2021 Aug 31:1-5. doi: 10.1017/S1047951121003504. Epub ahead of print. PMID: 34462025. https://pubmed.ncbi.nlm.nih.gov/34462025/
Kosiorek A, Donofrio MT, Zurakowski D, Reitz JG, Tague L, Murnick J, Axt-Fliedner R, Limperopoulos C, Yerebakan C, Carpenter JL Predictors of Neurological Outcome Following Infant Cardiac Surgery Without Deep Hypothermic Circulatory Arrest Pediatr Cardiol. 2021 Aug 17. doi: 10.1007/s00246-021-02693-z. Epub ahead of print. PMID: 34402933 https://pubmed.ncbi.nlm.nih.gov/34402933/
De Asis-Cruz J, Lopez C, Kapse K, Quistorff J, Vezina G, Donofrio M, Limperopoulos C In-utero MRI identifies altered resting state networks in fetuses with complex congenital heart disease. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
Lu Y-C, Andescavage N, Kapse K, Andersen N, Lopez C, Quistorff J, Henderson D, Bulas D, Krishnan A, Donofrio MT, du Plessis AJ, Limperopoulos C Maternal anxiety alters in vivo placental morphology and texture in pregnancies complicated by fetal congenital heart disease. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 1, 2021.
Schlatterer SD, Govindan RB, Murnick J, Barnett SD, Lopez C, Al-Shargabi T, Donofrio MT, Mulkey SB, Limperopoulos C, du Plessis AJ. Early heart rate variability correlates with pre-operative brain injury score in infants with congenital heart disease. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
Sanapo L, Al-Shargabi T, Ahmadzia HK, Schidlow DN, Donofrio MT, Hitchings L, Khoury A, Larry Maxwell G, Baker R, Bulas DI, Gomez LM, du Plessis AJ
Fetal acute cerebral vasoreactivity to maternal hyperoxia in low-risk pregnancies: a cross-sectional study
Prenat Diagn. 2020;40(7):813-824. doi:10.1002/pd.5694 https://pubmed.ncbi.nlm.nih.gov/32274806/
Wu Y, Kapse K, Jacobs M, Andescavage N, Donofrio MT, Krishnan A, Vezina G, Wessel D, du Plessis A, Limperopoulos C
Association of maternal psychological distress with in utero brain development in fetuses with congenital heart disease
JAMA Pediatrics. 2020 Jan 13;174(3):e195316. doi:10.1001/jamapediatrics.2019.5316 PMCID: PMC6990726 https://pubmed.ncbi.nlm.nih.gov/31930365/
You W, Andescavage NN, Kapse K, Donofrio MT, Jacobs M, Limperopoulos C
Hemodynamic responses of the placenta and brain to maternal hyperoxia in fetuses with congenital heart disease by using blood oxygen-level dependent MRI
Radiology. 2020;294(1):141-148. doi:10.1148/radiol.2019190751 https://pubmed.ncbi.nlm.nih.gov/31687920/
Adams AD, Aggarwal N, Iqbal SN, Tague L, Skurow-Todd K, McCarter R, Donofrio MT
Umbilical cord blood gas in newborns with prenatal diagnosis of congenital heart disease: Insight into in-utero and delivery hemodynamics
Pediatr Cardiol. 2019;40(8):1575-1583. doi:10.1007/s00246-019-02189-x https://pubmed.ncbi.nlm.nih.gov/31471626/
Goldstone AB, Baiocchi M, Wypij D, Stopp C, Andropoulos DB, Atallah J, Atz AM, Beca J, Donofrio MT, Duncan K, Ghanayem NS, Goldberg CS, Hövels-Gürich H, Ichida F, Jacobs JP, Justo R, Latal B, Li JS, Mahle WT, McQuillen PS, Menon SC, Pike NA, Pizarro C, Shekerdemian LS, Synnes A, Williams IA, Bellinger DC, Newburger J, Gaynor JW
The Bayley-III scale may underestimate neurodevelopmental disability after cardiac surgery in infants
Eur J Cardiothorac Surg. 2020;57(1):63-71. doi:10.1093/ejcts/ezz123 https://pubmed.ncbi.nlm.nih.gov/31006006/
Schlatterer SD, Murnick J, Jacobs M, White L, Donofrio MT, Limperopoulos C
Placental pathology and neuroimaging correlates in neonates with congenital heart disease
Scientific Reports. 2019 Mar 11;9(1):4137. doi: 10.1038/s41598-019-40894-y. PMCID: PMC6411739 https://pubmed.ncbi.nlm.nih.gov/30858514/
Cuneo BF, Sonesson SE, Levasseur S, Moon-Grady AJ, Krishnan A, Donofrio MT, Raboisson MJ, Hornberger LK, Van Eerden P, Sinkovskaya E, Abuhamad A, Arya B, Szwast A, Gardiner H, Jacobs K, Freire G, Howley L, Lam A, Kaizer AM, Benson DW, Jaeggi E
Home monitoring for fetal heart rhythm during Anti-Ro pregnancies
[published correction appears in J Am Coll Cardiol. 2019 Jan 8;73(1):120]. J Am Coll Cardiol. 2018;72(16):1940-1951. doi:10.1016/j.jacc.2018.07.076 https://pubmed.ncbi.nlm.nih.gov/30309472/
Sanz JH, Wang J, Berl MM, Armour AC, Cheng YI, Donofrio MT
Executive Function and Psychosocial Quality of Life in School Age Children with Congenital Heart Disease
J Pediatr. 2018;202:63-69. doi:10.1016/j.jpeds.2018.07.018 https://pubmed.ncbi.nlm.nih.gov/30243535/
Clur SB, Vink AS, Etheridge SP, Robles de Medina PG, Rydberg A, Ackerman MJ, Wilde AA, Blom NA, Benson DW, Herberg U, Donofrio MT, Cuneo BF
Left ventricular isovolumetric relaxation time is prolonged in fetal Long-QT Syndrome
Circ Arrhythm Electrophysiol. 2018;11(4):e005797. doi:10.1161/CIRCEP.117.005797 https://pubmed.ncbi.nlm.nih.gov/29654130/
Scheel A, Ssinabulya I, Aliku T, Bradley-Hewitt T, Clauss A, Clauss S, Crawford L, DeWyer A, Donofrio MT, Jacobs M, Klein J, Moore TE, Okello E, Scheel J, Shaw R, Sable C, Lwabi P, Watkins DA, Beaton A
Community study to uncover the full spectrum of rheumatic heart disease in Uganda
Heart. 2019;105(1):60-66. doi:10.1136/heartjnl-2018-313171 https://pubmed.ncbi.nlm.nih.gov/30068532/