Mary T. Donofrio, M.D.

Medical Director, Prenatal Cardiology Program
Co-Director, Cardiac Neurodevelopmental Outcome Program

Mary T. Donofrio, M.D., Medical Director of the Prenatal Cardiology Program at Children’s National, is an international expert in fetal cardiology and has published over 100 papers, including the American Heart Association Scientific Statement on the Diagnosis and Treatment of Fetal Cardiac Disease. Dr. Donofrio is one of the founders and current president of the Fetal Heart Society, a non-profit organization created to advance the art and science of prenatal cardiovascular medicine; to improve the understanding of in-utero cardiovascular physiology by fostering scientific research, organized research collaboration and mentorship; and to educate medical and research professionals through scientific publications, education and meetings.

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Address: 111 Michigan Ave NW, Washington, DC 20010

Email: fetalbrain@childrensnational.org

Department: MRI Lab

Recent Publications & Presentations

2021 De Asis-Cruz J, Lopez C, Kapse K, Quistorff J, Vezina G, Donofrio M, Limperopoulos C In-utero MRI identifies altered resting state networks in fetuses with complex congenital heart disease. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
2021 Lu Y-C, Andescavage N, Kapse K, Andersen N, Lopez C, Quistorff J, Henderson D, Bulas D, Krishnan A, Donofrio MT, du Plessis AJ, Limperopoulos C Maternal anxiety alters in vivo placental morphology and texture in pregnancies complicated by fetal congenital heart disease. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 1, 2021.
2021 Schlatterer SD, Govindan RB, Murnick J, Barnett SD, Lopez C, Al-Shargabi T, Donofrio MT, Mulkey SB, Limperopoulos C, du Plessis AJ. Early heart rate variability correlates with pre-operative brain injury score in infants with congenital heart disease. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
2020 Barker PCA, Lewin MB, Donofrio MT, Altman CA, Ensing GJ, Arya B, Swaminathan M Specific considerations for pediatric, fetal, and congenital heart disease patients and echocardiography service providers during the 2019 novel coronavirus outbreak: Council on Pediatric and Congenital Heart Disease Supplement to the Statement of the American Society of Echocardiography: Endorsed by the Society of Pediatric Echocardiography and the Fetal Heart Society J Am Soc Echocardiogr. 2020;33(6):658-665. doi:10.1016/j.echo.2020.04.005 https://pubmed.ncbi.nlm.nih.gov/29436733/
2020 Sanapo L, Al-Shargabi T, Ahmadzia HK, Schidlow DN, Donofrio MT, Hitchings L, Khoury A, Larry Maxwell G, Baker R, Bulas DI, Gomez LM, du Plessis AJ Fetal acute cerebral vasoreactivity to maternal hyperoxia in low-risk pregnancies: a cross-sectional study Prenat Diagn. 2020;40(7):813-824. doi:10.1002/pd.5694 https://pubmed.ncbi.nlm.nih.gov/32274806/
2020 Wu Y, Kapse K, Jacobs M, Andescavage N, Donofrio MT, Krishnan A, Vezina G, Wessel D, du Plessis A, Limperopoulos C Association of maternal psychological distress with in utero brain development in fetuses with congenital heart disease JAMA Pediatrics. 2020 Jan 13;174(3):e195316. doi:10.1001/jamapediatrics.2019.5316 PMCID: PMC6990726 https://pubmed.ncbi.nlm.nih.gov/31930365/
2020 You W, Andescavage NN, Kapse K, Donofrio MT, Jacobs M, Limperopoulos C Hemodynamic responses of the placenta and brain to maternal hyperoxia in fetuses with congenital heart disease by using blood oxygen-level dependent MRI Radiology. 2020;294(1):141-148. doi:10.1148/radiol.2019190751 https://pubmed.ncbi.nlm.nih.gov/31687920/
2020 Adams AD, Aggarwal N, Fries MH, Donofrio MT, Iqbal SN Neonatal and maternal outcomes of pregnancies with a fetal diagnosis of congenital heart disease using a standardized delivery room management protocol J Perinatol. 2020;40(2):316-323. doi:10.1038/s41372-019-0528-1 https://pubmed.ncbi.nlm.nih.gov/31611616/
2020 Adams AD, Aggarwal N, Iqbal SN, Tague L, Skurow-Todd K, McCarter R, Donofrio MT Umbilical cord blood gas in newborns with prenatal diagnosis of congenital heart disease: Insight into in-utero and delivery hemodynamics Pediatr Cardiol. 2019;40(8):1575-1583. doi:10.1007/s00246-019-02189-x https://pubmed.ncbi.nlm.nih.gov/31471626/
2020 Goldstone AB, Baiocchi M, Wypij D, Stopp C, Andropoulos DB, Atallah J, Atz AM, Beca J, Donofrio MT, Duncan K, Ghanayem NS, Goldberg CS, Hövels-Gürich H, Ichida F, Jacobs JP, Justo R, Latal B, Li JS, Mahle WT, McQuillen PS, Menon SC, Pike NA, Pizarro C, Shekerdemian LS, Synnes A, Williams IA, Bellinger DC, Newburger J, Gaynor JW The Bayley-III scale may underestimate neurodevelopmental disability after cardiac surgery in infants Eur J Cardiothorac Surg. 2020;57(1):63-71. doi:10.1093/ejcts/ezz123 https://pubmed.ncbi.nlm.nih.gov/31006006/
2019 Schlatterer SD, Murnick J, Jacobs M, White L, Donofrio MT, Limperopoulos C Placental pathology and neuroimaging correlates in neonates with congenital heart disease Scientific Reports. 2019 Mar 11;9(1):4137. doi: 10.1038/s41598-019-40894-y. PMCID: PMC6411739 https://pubmed.ncbi.nlm.nih.gov/30858514/
2019 Cuneo BF, Sonesson SE, Levasseur S, Moon-Grady AJ, Krishnan A, Donofrio MT, Raboisson MJ, Hornberger LK, Van Eerden P, Sinkovskaya E, Abuhamad A, Arya B, Szwast A, Gardiner H, Jacobs K, Freire G, Howley L, Lam A, Kaizer AM, Benson DW, Jaeggi E Home monitoring for fetal heart rhythm during Anti-Ro pregnancies [published correction appears in J Am Coll Cardiol. 2019 Jan 8;73(1):120]. J Am Coll Cardiol. 2018;72(16):1940-1951. doi:10.1016/j.jacc.2018.07.076 https://pubmed.ncbi.nlm.nih.gov/30309472/
2018 Peyvandi S, Donofrio MT Circulatory changes and cerebral blood flow and oxygenation during transition in newborns with congenital heart disease Semin Pediatr Neurol. 2018;28:38-47. doi:10.1016/j.spen.2018.05.005 https://pubmed.ncbi.nlm.nih.gov/30522727/
2018 Sanz JH, Wang J, Berl MM, Armour AC, Cheng YI, Donofrio MT Executive Function and Psychosocial Quality of Life in School Age Children with Congenital Heart Disease J Pediatr. 2018;202:63-69. doi:10.1016/j.jpeds.2018.07.018 https://pubmed.ncbi.nlm.nih.gov/30243535/
2018 Donofrio MT Predicting the future: Delivery room planning of congenital heart disease diagnosed by fetal echocardiography Am J Perinatol. 2018;35(6):549-552. doi:10.1055/s-0038-1637764 https://pubmed.ncbi.nlm.nih.gov/29694994/
2018 Clur SB, Vink AS, Etheridge SP, Robles de Medina PG, Rydberg A, Ackerman MJ, Wilde AA, Blom NA, Benson DW, Herberg U, Donofrio MT, Cuneo BF Left ventricular isovolumetric relaxation time is prolonged in fetal Long-QT Syndrome Circ Arrhythm Electrophysiol. 2018;11(4):e005797. doi:10.1161/CIRCEP.117.005797 https://pubmed.ncbi.nlm.nih.gov/29654130/
2018 Scheel A, Ssinabulya I, Aliku T, Bradley-Hewitt T, Clauss A, Clauss S, Crawford L, DeWyer A, Donofrio MT, Jacobs M, Klein J, Moore TE, Okello E, Scheel J, Shaw R, Sable C, Lwabi P, Watkins DA, Beaton A Community study to uncover the full spectrum of rheumatic heart disease in Uganda Heart. 2019;105(1):60-66. doi:10.1136/heartjnl-2018-313171 https://pubmed.ncbi.nlm.nih.gov/30068532/

Mary T. Donofrio, M.D.

Medical Director, Prenatal Cardiology Program Co-Director, Cardiac Neurodevelopmental Outcome Program

Recent Publications & Presentations

Medical Director, Prenatal Cardiology Program
Co-Director, Cardiac Neurodevelopmental Outcome Program