Loading...

Josepheen De Asis Cruz, M.D., Ph.D.

Assistant Professor

Josepheen De Asis Cruz, M.D., Ph.D., is an Assistant Professor who joined the Developing Brain Institute in September 2014. Dr. Cruz’s research focuses on characterizing neurodevelopment in fetuses and neonates using resting state functional MRI (fMRI). She joined the Institute after finishing her Ph.D. at Baylor College of Medicine where she studied neural markers of impaired social cognition in autism spectrum disorders using fMRI. Prior to her Ph.D., she obtained her bachelor’s degree in psychology and medical degree at the University of the Philippines.


Address: 111 Michigan Ave NW, Washington, DC 20010
Email: fetalbrain@childrensnational.org
Department: MRI Lab

Recent Publications & Presentations

2023 | May
De Asis-Cruz J, Limperopoulos C.
Harnessing the power of advanced fetal neuroimaging to understand in utero footprints for later neuropsychiatric disorders. Biol Psychiatry. 2023 May 15;93(10):867-879. doi: 10.1016/j.biopsych.2022.11.019. Epub 2022 Dec 5. PMID: 36804195.
https://pubmed.ncbi.nlm.nih.gov/36804195/
Kim JH, De Asis-Cruz J, Krishnamurthy D, Limperopoulos C.
Towards a more informative representation of the fetal-neonatal brain connectome using variational autoencoder
Elife. 2023 May 15;12:e80878. doi: 10.7554/eLife.80878. Epub ahead of print. PMID: 37184067 https://pubmed.ncbi.nlm.nih.gov/37184067/
2023 | April
Kim JH, De Asis-Cruz J, Kapse K, Limperopoulos C.
Systematic evaluation of head motion on resting-state functional connectivity MRI in the neonate. Hum Brain Mapp. 2023 Apr 1;44(5):1934-1948. doi: 10.1002/hbm.26183. Epub 2022 Dec 28. PMID: 36576333; PMCID: PMC9980896.
https://pubmed.ncbi.nlm.nih.gov/36576333/
2023 | March
Chirumamilla VC, Hitchings L, Mulkey SB, Anwar T, Baker R, Larry Maxwell G, De Asis-Cruz J, Kapse K, Limperopoulos C, du Plessis A, Govindan RB.
Functional brain network properties of healthy full-term newborns quantified by scalp and source-reconstructed EEG. Clin Neurophysiol. 2023 Mar;147:72-80. doi: 10.1016/j.clinph.2023.01.005. Epub 2023 Jan 23. PMID: 36731349; PMCID: PMC9975070.
https://pubmed.ncbi.nlm.nih.gov/36731349/
2022
Largent A, De Asis-Cruz J, Kapse K, Barnett SD, Murnick J, Basu S, Andersen N, Norman S, Andescavage N, Limperopoulos C.
Automatic brain segmentation in preterm infants with post-hemorrhagic hydrocephalus using 3D Bayesian U-Net Hum Brain Mapp. 2022 Jan 13. doi: 10.1002/hbm.25762. Epub ahead of print. PMID: 35023255 https://pubmed.ncbi.nlm.nih.gov/35023255/
2021
De Asis-Cruz, J, Barnett, S.D., Kim, J.H. and Limperopoulos, C.
Functional Connectivity-Derived Optimal Gestational-Age Cut Points for Fetal Brain Network Maturity
11(7), p.921.2021. https://www.mdpi.com
2021
De Asis-Cruz J, Andersen N, Kapse K, Khrisnamurthy D, Quistorff J, Lopez C, Vezina G, Limperopoulos C
Global Network Organization of the Fetal Functional Connectome.
Cereb Cortex. 2021 May 10;31(6):3034-3046. doi: 10.1093/cercor/bhaa410. PMID: 33558873; PMCID: PMC8107792. https://pubmed.ncbi.nlm.nih.gov/33558873/
2021
De Asis-Cruz J and Limperopoulos C.
Chapter 24 - Linking congenital heart disease and brain functional connectivity in newborns.
In Martin CR, Preedy VR, Rajendram R, eds. Diagnosis, Management and Modeling of Neurodevelopmental Disorders: Academic Press; 2021: 275-284. ISBN 9780128179888 https://www.sciencedirect.com/
2021
De Asis-Cruz J, Lopez C, Kapse K, Quistorff J, Vezina G, Donofrio M, Limperopoulos C In-utero MRI identifies altered resting state networks in fetuses with complex congenital heart disease. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
2021
Cook KM, De Asis-Cruz J, Lopez C, Quistorff J, Kapse K, Andresen N, Vezina G, Limperopoulos C In utero MRI differentiates male and female human fetal brain functional connectivity. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 3, 2021.
2021
Basu S, Espinosa K, Pradhan S, Kapse K, De-Asis Cruz J, Kapse A, Norman S, Fischer D, Andescavage N, Limperopoulos C Cerebellar structure, function and neurodevelopmental outcomes in very preterm infants. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
2021
Axel Largent PhD, Kushal Kapse MS, Scott D. Barnett PhD, Josepheen De Asis‐Cruz MD, PhD, Matthew Whitehead MD, Jonathan Murnick MD, PhD, Li Zhao PhD, Nicole Andersen BA, Jessica Quistorff MPH, Catherine Lopez MS, Catherine Limperopoulos PhD
Image Quality Assessment of Fetal Brain MRI Using Multi‐Instance Deep Learning Methods
[published online ahead of print, 2021 Apr 23]. J Magn Reson Imaging 2021 Apr 23. doi: 10.1002/jmri.27649. https://onlinelibrary.wiley.com
2020
De Asis-Cruz J, Krishnamurthy D, Zhao L, Kapse K, Vezina G, Andescavage N, Quistorff J, Lopez C, Limperopoulos C.
Association of prenatal maternal anxiety with fetal regional brain connectivity JAMA Network Open. Published 2020, Dec. 7;3(12):e2022349. doi:10.1001/jamanetworkopen.2020.22349 https://pubmed.ncbi.nlm.nih.gov/33284334/
2020
De Asis-Cruz J, Kapse K, Basu SK, Said M, Scheinost D, Murnick J, Chang T, du Plessis A, Limperopoulos C.
Functional brain connectivity in ex utero premature infants compared to in utero fetuses
[published online ahead of print, 2020 Jun 11]. Neuroimage. 2020;219:117043. doi:10.1016/j.neuroimage.2020.117043 https://pubmed.ncbi.nlm.nih.gov/32534962/
2019
Bouyssi-Kobar M, De Asis-Cruz J, Murnick J, Chang T, Limperopoulos C.
Altered functional brain network integration, segregation and modularity in very preterm infants at term equivalent age.
Journal of Pediatrics 2019;213:13-21.e1. doi:10.1016/j.jpeds.2019.06.030 https://pubmed.ncbi.nlm.nih.gov/31358292/


Book Chapters

2021
De Asis-Cruz J and Limperopoulos C. Chapter 24 - Linking congenital heart disease and brain functional connectivity in newborns. In Martin CR, Preedy VR, Rajendram R, eds
Diagnosis, Management and Modeling of Neurodevelopmental Disorders Academic Press; 2021: 275-284. ISBN 9780128179888 https://doi.org/10.1016/B978-0-12-817988-8.00024-5