Loading...

Adré J. du Plessis, M.B.Ch.B.

Director of Prenatal Pediatrics Institute

Adré J. du Plessis, M.B.Ch.B., is a full-time attending in prenatal neurology, as well as the Director of the Prenatal Pediatrics Institute, Division Chief of Prenatal and Transitional Pediatrics, and Director of the Prenatal Brain Program at Children’s National Hospital. In addition, Dr. du Plessis is a Professor of Pediatrics and Neurology at the George Washington University School of Medicine. He is a leading international expert in the normal and abnormal development of the brain, as well as the mechanisms of injury to the immature brain. Dr. du Plessis specializes in prenatal neurology, particularly fetal brain developmental anomalies, and the advanced fetal imaging that is used to diagnose these conditions in early pregnancy.

As a fetal-neonatal neurologist, his career-long research focus has been on the nervous system of the fetus and newborn, the hazards and mechanisms of injury, and the potential prevention of insult to the brain. Almost 25 years ago, he was a founding director of the first dedicated clinical program for Neonatal (and later Fetal-Neonatal) Neurology at Boston Children’s Hospital and Harvard’s Longwood-area neonatal intensive care units. Supported initially by philanthropic funds and subsequently by an NIH K24 award (NS057568), Dr. du Plessis developed the first dedicated clinical research program for the immature brain. Since becoming Chief of Prenatal and Transitional Medicine and Director of the Prenatal Pediatrics Institute at Children’s National, he has overseen the development of a multidisciplinary clinical, research, and training program with a unique focus on the developing brain. The Prenatal Pediatrics Institute is pioneering prenatal pediatrics as a new discipline, one in which caring for children starts before birth, and focusing on conditions that affect the intrauterine environment during fetal development with consequences across the lifespan.


Address: 111 Michigan Ave NW, Washington, DC 20010
Email: fetalbrain@childrensnational.org
Department: MRI Lab

Recent Publications & Presentations

2022 | April
Wu Y, Espinosa KM, Barnett SD, Kapse A, Quistorff JL, Lopez C, Andescavage N, Pradhan S, Lu YC, Kapse K, Henderson D, Vezina G, Wessel D, du Plessis AJ, Limperopoulos C.
Association of elevated maternal psychological distress, altered fetal brain, and offspring cognitive and social-emotional outcomes at 18 months. JAMA Netw Open. 2022 Apr 1;5(4):e229244. doi: 10.1001/jamanetworkopen.2022.9244. PMID: 35486403; PMCID: PMC9055453. https://pubmed.ncbi.nlm.nih.gov/35486403/
2022
Limperopoulos C, Wessel DL, du Plessis AJ
Understanding the maternal-fetal environment and the birth of prenatal pediatrics J Am Heart Assoc. 2022 Jan 11:e023807. doi: 10.1161/JAHA.121.023807. Epub ahead of print. PMID: 35014863 https://pubmed.ncbi.nlm.nih.gov/35014863/
2022
Basu SK, Pradhan S, Barnett SD, Mikkelsen M, Kapse KJ, Murnick J, Quistorff JL, Lopez CA, du Plessis AJ, Limperopoulos C
Regional differences in gamma-aminobutyric acid and glutamate concentrations in the healthy newborn brain AJNR Am J Neuroradiol. 2022 Jan;43(1):125-131. doi: 10.3174/ajnr.A7336. Epub 2021 Nov 11. PMID: 34764083 https://pubmed.ncbi.nlm.nih.gov/34764083/
2021
Schlatterer SD, Govindan RB, Murnick J, Barnett SD, Lopez C, Donofrio MT, Mulkey SB, Limperopoulos C, du Plessis AJ
In infants with congenital heart disease autonomic dysfunction is associated with pre-operative brain injury Pediatr Res. 2021 Dec 28. doi: 10.1038/s41390-021-01931-7. Epub ahead of print. PMID: 34963700 https://pubmed.ncbi.nlm.nih.gov/34963700/
2021
Wu Y, Lu YC, Kapse K, Jacobs M, Andescavage N, Donofrio MT, Lopez C, Quistorff JL, Vezina G, Krishnan A, du Plessis AJ, Limperopoulos C
In utero MRI identifies impaired second trimester subplate growth in fetuses with congenital heart disease
Cereb Cortex. 2021 Oct 28:bhab386. doi: 10.1093/cercor/bhab386. Epub ahead of print. PMID: 34882775 https://pubmed.ncbi.nlm.nih.gov/34882775/
2021
Wu Y, Andescavage N, Lopez C, Quistorff JL, Donofrio MT, du Plessis AJ, Limperopoulos C.
Maternal mental distress and cortisol levels in pregnancies with congenital heart disease. Cardiol Young. 2021 Aug 31:1-5. doi: 10.1017/S1047951121003504. Epub ahead of print. PMID: 34462025. https://pubmed.ncbi.nlm.nih.gov/34462025/
2021
Lu Y-C, Andescavage N, Saeed H, Quistorff J, Lopez C, Henderson D, Kapse K, Vezina G, du Plessis AJ, Limperopoulos C Structural changes of the human fetal brain during the COVID-19 pandemic. Society for Pediatric Research (SPR) Plenary Series: Best of SPR Featured Abstracts. Pediatric Academic Societies 2021 Virtual Meeting, May 4, 2021.
2021
Lu Y-C, Andescavage N, Saeed H, Kapse K, Andersen N, Lopez C, Henderson D, Bulas D, du Plessis AJ, Limperopoulos C Influence of the COVID-19 pandemic on human placental morphology and texture. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 3, 2021.
2021
Lu Y-C, Andescavage N, Kapse K, Andersen N, Lopez C, Quistorff J, Henderson D, Bulas D, Krishnan A, Donofrio MT, du Plessis AJ, Limperopoulos C Maternal anxiety alters in vivo placental morphology and texture in pregnancies complicated by fetal congenital heart disease. Platform presentation. Pediatric Academic Societies 2021 Virtual Meeting, May 1, 2021.
2021
Schlatterer SD, Govindan RB, Murnick J, Barnett SD, Lopez C, Al-Shargabi T, Donofrio MT, Mulkey SB, Limperopoulos C, du Plessis AJ. Early heart rate variability correlates with pre-operative brain injury score in infants with congenital heart disease. Poster presentation. Pediatric Academic Societies 2021 Virtual Meeting, April 30, 2021.
2021
Zun Z, Kapse K, Jacobs M, Basu S, Said M, Andersen N, Murnick J, Chang T, du Plessis A, Limperopoulos C.
Longitudinal Trajectories of Regional Cerebral Blood Flow in Very Preterm Infants during Third Trimester Ex Utero Development Assessed with MRI. Radiology. 2021 Mar 30:202423. doi: 10.1148/radiol.2021202423. Epub ahead of print. PMID: 33787337. https://pubmed.ncbi.nlm.nih.gov/33787337/
2021
Lu YC, Kapse K, Andersen N, Quistorff J, Lopez C, Fry A, Cheng J, Andescavage N, Wu Y, Espinosa K, Vezina G, du Plessis A, Limperopoulos C.
Association between socioeconomic status and in utero fetal brain development. JAMA Network Open. Published 2021, Mar 1;4(3):e213526. doi: 10.1001/jamanetworkopen.2021.3526. PMID: 33779746. https://pubmed.ncbi.nlm.nih.gov/33779746/
2020
Wu Y, Yuan-Chiao L, Jacobs M, Pradhan S, Kapse K, Zhao L, Andescavage N, Vezina G, du Plessis A, Limperopoulos C.
Association of prenatal maternal psychological distress with fetal brain growth, metabolism, and cortical maturation.
JAMA Network Open. 2020 Jan 3;3(1):e1919940. PMC6991285 https://pubmed.ncbi.nlm.nih.gov/31995213/
2020
Basu SK, Pradhan S, Jacobs MB, Said M, Kapse K, Murnick J, Whitehead MT, Chang T, du Plessis AJ, Limperopoulos C.
Age and sex influences gamma-aminobutyric acid concentrations in the developing brain of very premature infants.
Sci Rep. 2020 Jun 29;10(1):10549. doi: 10.1038/s41598-020-67188-y.Sci Rep. 2020. PMID: 32601466 https://pubmed.ncbi.nlm.nih.gov/32601466/
2020
De Asis-Cruz J, Kapse K, Basu SK, Said M, Scheinost D, Murnick J, Chang T, du Plessis A, Limperopoulos C
Functional brain connectivity in ex utero premature infants compared to in utero fetuses.
Neuroimage. 2020 Oct 1;219:117043. doi: 10.1016/j.neuroimage.2020.117043. Epub 2020 Jun 11. https://pubmed.ncbi.nlm.nih.gov/32534962/
2020
Mulkey SB, Govindan RB, Hitchings L, Al-Shargabi T, Herrera N, Swisher CB, Eze A Jr, Russo S, Schlatterer SD, Jacobs MB, McCarter R, Kline A, Maxwell GL, Baker R, du Plessis AJ
Autonomic nervous system maturation in the premature extrauterine milieu.
Pediatr Res. 2020 May 12. doi: 10.1038/s41390-020-0952-0. https://pubmed.ncbi.nlm.nih.gov/32396923/
2017
Andescavage N, du Plessis AJ, Evangelou I, Vezina G, Robertson RR, Limperopoulos C.
Complex trajectories of brain development in the healthy human fetus.
Cerebral Cortex. 2017 Nov 1;27(11):5274-83. PMID: 27799276 https://pubmed.ncbi.nlm.nih.gov/27799276/