- Cerebellar Development
- Study Summaries
- The ABC Study
Developing Brain Research Laboratory
The Developing Brain Research Laboratory, directed by Catherine Limperopoulos, PhD , is housed in the department of Diagnostic Imaging and Radiology and affiliated with the Fetal and Transitional Medicine Program at Children’s National Health System. Our research focuses on the developing brain, both in utero and in the newborn stages of life.
We are developing advanced MRI techniques to examine the structure, connectivity, and metabolism of the brain in ways that cannot be done with conventional MRI studies. It is our long-term goal to be able to identify babies with impaired brain growth as soon as possible, so that the proper interventions and clinical planning can take place.
Cerebellar Development in the Preterm Infant
This research study seeks to better understand brain development in premature babies. We are particularly interested in an area of the brain called the cerebellum. The cerebellum is responsible for motor coordination of the body and also plays a role in higher functions such as attention, cognition and language.
This study investigates the development of the cerebellum in premature babies, and its relationship with early development.
1) Antecedents of Impaired Brain Development in Fetuses with Congenital Heart Disease (Healthy Starts for Tiny Hearts Study)
In this study we seek to identify whether, why, and when brain development is affected in the unborn baby diagnosed with Congenital Heart Disease. The testing involves two fetal MRI scans and echocardiograms during the second half of pregnancy, two brain MRI scans after birth (pre- and post-operatively), and neurobehavioral evaluation of the newborn baby.
2) Cerebellar Development in the Pre-Term Infant (CRIB Study)
Given that babies born prematurely are at risk for cerebellar injury and poor long-term developmental outcomes, in this study we use serial MRI imaging and bedside neurobehavioral assessments to study this critical period in a premature infant’s life. This study involves a preterm MRI in an MRI-safe incubator, and a term-equivalent MRI, in addition to bedside neurobehavioral assessments and two long-term developmental follow-up visits.
Brain Development in the Fetus with Congenital Heart Disease – The ABC Study
The ABC Study – or Antenatal Brain Cardiac study – Seeks to better understand brain development in babies with congenital heart defects. Although infants with a heart problem are at greater risk for problems with brain development, the precise effect, if any, of the heart problem on the development of the brain remains poorly understood.
We study the brain as it is developing during pregnancy, through a technique called [fetal MRI]. Enrolled babies have also an MRI scan shortly after birth to look at the brain in the newborn period. We also aim to evaluate the le relationship between brain development and cognitive and social-behavioral development in this population.
You are Invited to Join a Fetal Brain Study.
We would like to invite eligible pregnant women to join an important study
at Children’s National Health System.
We are studying brain development during pregnancy in unborn babies with congenital heart disease. Most of these babies do not develop brain-related problems, but some do. In this study, we will gather information to help us identify future babies at risk for brain-related problems. This in turn will help us develop treatments that prevent such problems and ensure the best possible outcome for babies with congenital heart disease in the future.
Cerebellar Development in the Preterm Infant
Publications and Highlights
Abnormal Placenta Growth & Impaired Growth of Fetuses with CHDPublished | March 15th 2016
A team of researchers from Children's National Health System used 3-D volumetric magnetic resonance imaging (MRI) in an innovative study.Read More
Novel applications of quantitative MRI for the fetal brainPublished | April 27th 2011
This paper provides an overview of the role of advanced neuroimaging techniques to study in vivo brain maturation and explores the application of a range of new quantitative imaging biomarkers that can be used clinically to monitor high-risk pregnancies.Read More
Injury to the Premature Cerebellum: Outcome is Related to Remote Cortical DevelopmentPublished | November 11th 2012
In the current study, we examine the relationship between these remote regional impairments of cerebral volumetric growth and domain-specific functional deficits in these children.Read More
Cerebellar Injury in the Premature Infant Is Associated With Impaired Growth of Specific Cerebral RegionsPublished | 2010
In this study, we hypothesize that this remote growth restriction is region specific in the cerebrum. In a prospectively enrolled cohort of 38 expreterm infants with isolated cerebellar injury by neonatal MRI, we performed follow-up volumetric MRI studies at a mean postnatal age of 35.5 - 13.8 mo.Read More
Robust motion correction and outlier rejection of in vivo functional MR images of the fetal brain and placenta during maternal hyperoxia
Subject motion is a major challenge in functional magnetic resonance imaging studies (fMRI) of the fetal brain and placenta during maternal hyperoxia. We propose a motion correction and volume outlier rejection method for the correction of severe motion artifacts in both fetal brain and placenta. The method is optimized to the experimental design by processing different phases of acquisition separately.More
Prevalence and spectrum of in utero structural brain abnormalities in fetuses with complex congenital heart disease.
Brain injury is a major complication in neonates with complex congenital heart disease. Preliminary evidence suggests that fetuses with congenital heart disease are at greater risk for brain abnormalities. However, the nature and frequency of these brain abnormalities detected by conventional fetal MR imaging has not been examined prospectively.More